Evidence map›Paper›PMID 28817620›Full record

ArticlePloS one2017

GTSP1 expression in non-smoker and non-drinker patients with squamous cell carcinoma of the head and neck.

Pamela de Oliveira Soares, Patrícia Maluf Cury, Rossana Verónica Mendoza López, Cláudio Roberto Cernea, Erika Erina Fukuyama, David Livingstone Alves Figueiredo, Francisco Gorgonio da Nobrega, Otavio Alberto Curioni, Fabio Daumas Nunes, Raquel Ajub Moyses and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
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  6. Article
  7. GlutathioneDrug design, development and therapy · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 1 country.

Pamela de Oliveira SoaresDepartment of Head and Neck Surgery, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo / LIM-28-São Paulo, SP, Brazil.
Patrícia Maluf CuryDepartment of Pathology and Legal Medicine-Faculdade de Medicina de São José do Rio Preto São José do Rio Preto, SP, Brazil.
Rossana Verónica Mendoza LópezCenter for Research in Oncology, ICESP- Instituto do Câncer do Estado de São Paulo, SP, Brazil.
Cláudio Roberto CerneaDepartment of Head and Neck Surgery, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo / LIM-28-São Paulo, SP, Brazil.
Erika Erina FukuyamaDepartment of Head and Neck Surgery, Instituto do Câncer Arnaldo Vieira de Carvalho, São Paulo, SP, Brazil.
David Livingstone Alves FigueiredoDepartment of Pharmacy, Universidade Estadual do Centro-Oeste, Guarapuava, PR, Brazil.
Francisco Gorgonio da NobregaInstitute of Science and Technology, Universidade Federal de São Paulo, São José dos Campos, SP, Brazil.
Otavio Alberto CurioniDepartment of Otorhinolaryngology and Head and Neck Surgery, Hospital Heliópolis São Paulo, SP, Brazil.
Fabio Daumas NunesDepartment of Oral Pathology Faculdade de Odontologia da Universidade de São Paulo, São Paulo, SP, Brazil.
Raquel Ajub MoysesDepartment of Head and Neck Surgery, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo / LIM-28-São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-0872-9870
Maria Lúcia Bueno GarciaDepartment of Internal Medicine, Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil.
HEAD AND NECK GENOME PROJECT–GENCAPO
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRFaculdade de Medicina de São José do Rio Preto · BRHospital Heliópolis · BRInstituto do Câncer do Estado de São Paulo · BRUniversidade de São Paulo · BRUniversidade Estadual do Centro-Oeste · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe main risk factors for head and neck squamous cell carcinoma (HNSCC) are tobacco and alcohol consumption and human papillomavirus (HPV) infection. However, in a subset of patients, no risk factors can be identified. Glutathione S-transferase π (GTSP1) is a carcinogen-detoxifying enzyme that is activated by exposure to carcinogens, and it is associated with a reduction in response to toxic therapies. We studied the expression of GTSP1 in tumor and non-tumor tissue samples from patients with and without these risks to identify whether GTSP1 expression differs according to exposure to carcinogens. MATERIALS AND

methodsNon-smoker/non-drinker (NSND) and smoker/drinker (SD) patients were matched according to age, gender, tumor site, TNM stage, grade and histological variants to establish 47 pairs of patients who have been previously tested for HPV. GTSP1 immunostaining was analyzed using a semi-quantitative method with scores ranging from 0 to 3 according to the area of immunostaining.

resultsGTSP1 expression was detected in the tumors of both groups. GTSP1 expression was higher in the non-tumor margins of SD patients (p = 0.004). There was no association between GTSP1 expression and positivity for HPV. No differences in survival were observed according to GTSP1 staining in tumors and non-tumor margins.

conclusionThis study showed that GTSP1 was expressed in tumors of HNSCC patients regardless of smoking, drinking or HPV infection status. The difference in GTSP1 expression in non-tumor margins between the two groups may have been due to two possible reasons. First, elevated GTSP1 expression in SD patients might be the result of activation of GTSP1 in response to exposure to carcinogens. Second, alternatively, impairment in the detoxifying system of GTSP1, as observed by the reduced expression of GTSP1, might make patients susceptible to carcinogens other than tobacco and alcohol, which may be the underlying mechanism of carcinogenesis in the absence of risk factors.

Indexed as

AdultAgedAged, 80 and overAlcohol DrinkingCarcinoma, Squamous CellCase-Control StudiesFemaleGlutathione TransferaseHead and Neck NeoplasmsHumansMaleMiddle AgedPapillomavirus InfectionsSmokingGlutathione Transferase

Identifiers

PMID28817620
PMCPMC5560606
OpenAlexW2748724953

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.