Evidence map›Paper›PMID 28817228›Full record

ArticleChemistry & biodiversity2017

Isolation of the New Antiplasmodial Butanolide, Malleastrumolide A, from Malleastrum sp. (Meliaceae) from Madagascar.

Yongle Du, Alexander K Abedi, Ana Lisa Valenciano, Maria L Fernández-Murga, Maria B Cassera, Vincent E Rasamison, Wendy L Applequist, James S Miller, David G I Kingston

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yongle DuDepartment of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA, 24061, USA.
Alexander K AbediDepartment of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA, 24061, USA.
Ana Lisa ValencianoDepartment of Biochemistry and Molecular Biology, Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, GA, 30602, USA.
Maria L Fernández-MurgaDepartment of Biochemistry and Virginia Tech Center for Drug Discovery, M/C 0308, Virginia Tech, Blacksburg, VA, 24061, USA.
Maria B CasseraDepartment of Biochemistry and Molecular Biology, Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, GA, 30602, USA.
Vincent E RasamisonCentre National d'Application des Recherches Pharmaceutiques, B.P 702, 101, Antananarivo, Madagascar.
Wendy L ApplequistMissouri Botanical Garden, P.O. Box 299, St. Louis, MO, 63166-0299, USA.
James S MillerMissouri Botanical Garden, P.O. Box 299, St. Louis, MO, 63166-0299, USA.
David G I KingstonDepartment of Chemistry and Virginia Tech Center for Drug Discovery, M/C 0212, Virginia Tech, Blacksburg, VA, 24061, USA.
Virginia Tech · USMissouri Botanical Garden · USUniversity of Georgia · USNational Application Center for Pharmaceutical Research · MG

Funding

BIODIVERSITY UTILIZATION IN MADAGASCAR AND SURINAMEU01TW000313 · FIC · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI KINGSTON, DAVID GEORGE IAN · 1993 to 2013
$9.5M
Discovery and Mechanism of Antimalarial Natural ProductsR01AT008088 · NCCIH · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI CASSERA, MARIA BELEN, CLEMENT, JASON ANDERSON · 2014 to 2018
$2.0M
FIC NIH HHS U01 TW000313NCCIH NIH HHS R01 AT008088
6 · The paper itself

Abstract

An extract of Malleastrum sp. (Meliaceae) collected in Madagascar by the Madagascar International Cooperative Biodiversity Group was found to have antimalarial activity, with an IC

Indexed as

4-ButyrolactoneAntimalarialsAntineoplastic Agents, PhytogenicCell Line, TumorCell ProliferationCircular DichroismHumansInhibitory Concentration 50Liquid-Liquid ExtractionMadagascarMagnetic Resonance SpectroscopyMass SpectrometryMeliaceaeMolecular ConformationPlant ExtractsPlasmodium falciparum4-ButyrolactoneAntimalarialsAntineoplastic Agents, Phytogenicmalleastrumolide APlant ExtractsAntiplasmodial activityButanolideMadagascarMalleastrumMeliaceae

Identifiers

PMID28817228
PMCPMC5739943
OpenAlexW2750044738

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.