Evidence map›Paper›PMID 28816616›Full record

ArticleRNA biology2018

Transfer-RNA-mediated enhancement of ribosomal proteins S6 kinases signaling for cell proliferation.

Nam Hoon Kwon, Mi Ran Lee, Jiwon Kong, Seung Kyun Park, Byung Joon Hwang, Byung Gyu Kim, Eun-Shin Lee, Hyeong-Gon Moon, Sunghoon Kim

Open access · hybridAbstract read
In one paragraph

Article in RNA biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Velcrin-induced selective cleavage of tRNANature chemical biology · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. tRNAJournal of clinical laboratory analysis · 2021
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. The dysregulation of tRNAs and tRNA derivatives in cancer.Journal of experimental & clinical cancer research : CR · 2018
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Nam Hoon Kwona Medicinal Bioconvergence Research Center , Seoul National University , Suwon , Gyeonggi , Korea.
Mi Ran Leea Medicinal Bioconvergence Research Center , Seoul National University , Suwon , Gyeonggi , Korea.
Jiwon Konga Medicinal Bioconvergence Research Center , Seoul National University , Suwon , Gyeonggi , Korea.
Seung Kyun Parkc Department of Molecular Bioscience , College of Biomedical Science, Kangwon National University , Chuncheon , Kangwon , Korea.
Byung Joon Hwangc Department of Molecular Bioscience , College of Biomedical Science, Kangwon National University , Chuncheon , Kangwon , Korea.
Byung Gyu Kima Medicinal Bioconvergence Research Center , Seoul National University , Suwon , Gyeonggi , Korea.
Eun-Shin Leed Department of Surgery , Seoul National University College of Medicine , Seoul , Korea.
Hyeong-Gon Moond Department of Surgery , Seoul National University College of Medicine , Seoul , Korea.
Sunghoon Kima Medicinal Bioconvergence Research Center , Seoul National University , Suwon , Gyeonggi , Korea.
Seoul National University · KRKangwon National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While transfer-RNAs (tRNAs) are known to transport amino acids to ribosome, new functions are being unveiled from tRNAs and their fragments beyond protein synthesis. Here we show that phosphorylation of 90-kDa RPS6K (ribosomal proteins S6 kinase) was enhanced by tRNA

Indexed as

Adaptor Proteins, Signal TransducingAmino AcidsAmino Acid SequenceAnimalsBreast NeoplasmsCell Line, TumorCell ProliferationErb-b2 Receptor Tyrosine KinasesFemaleGene Expression RegulationHEK293 CellsHT29 CellsHumansMCF-7 CellsMiceNIH 3T3 CellsAdaptor Proteins, Signal TransducingAmino AcidsERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesERBB3 protein, humanPA2G4 protein, humanReceptor, ErbB-3Ribosomal Protein S6 KinasesRibosomal Protein S6 Kinases, 90-kDaRNA-Binding ProteinsRNA, Small InterferingRNA, Transfer, LeuRPS6KA1 protein, humanRPS6KA4 protein, humancell proliferationEBP1MSKRSKtRNA

Identifiers

PMID28816616
PMCPMC6103689
OpenAlexW2746923169

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.