ArticleGut microbes2018
Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci.
Article in Gut microbes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Integrating host-microbiome multi-omics with machine learning: methods, benchmarks, and translational applications.Science China. Life sciences · 2026Review
- Genome-wide association study identifies host genetic variants influencing oral microbiota diversity and metabolic health.Scientific reports · 2024Article
- Scrutinizing microbiome determinism: why deterministic hypotheses about the microbiome are conceptually ungrounded.History and philosophy of the life sciences · 2024Article
- Downregulation of SLC9A8 Promotes Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer Cells via the IL6-JAK1/STAT3 Signaling Pathway.Digestive diseases and sciences · 2023Article
- Kernel-based genetic association analysis for microbiome phenotypes identifies host genetic drivers of beta-diversity.Microbiome · 2023Article
- Article
- Inflammatory Bowel Disease Risk Variants Are Associated with an Increased Risk of Skin Cancer.Inflammatory bowel diseases · 2022Article
- Host genetic factors related to innate immunity, environmental sensing and cellular functions are associated with human skin microbiota.Nature communications · 2022Article
- Modulation of macrophage inflammatory function through selective inhibition of the epigenetic reader protein SP140.BMC biology · 2022Article
- Combined effects of host genetics and diet on human gut microbiota and incident disease in a single population cohort.Nature genetics · 2022Article
- The host genetics affects gut microbiome diversity in Chinese depressed patients.Frontiers in genetics · 2022Article
- The Role of Plasma Membrane Sodium/Hydrogen Exchangers in Gastrointestinal Functions: Proliferation and Differentiation, Fluid/Electrolyte Transport and Barrier Integrity.Frontiers in physiology · 2022Review
- Targeting the cytoplasmic polyadenylation element-binding protein CPEB4 protects against diet-induced obesity and microbiome dysbiosis.Molecular metabolism · 2021Article
- Genome-wide association study in 8,956 German individuals identifies influence of ABO histo-blood groups on gut microbiome.Nature genetics · 2021Article
- The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases.Microbiome · 2020Article
- Effects of the DMRT1 genotype on the body weight and gut microbiota in the broiler chicken.Poultry science · 2020Article
- Of genes and microbes: solving the intricacies in host genomes.Protein & cell · 2018Review
- Article
- Host and Microbiome Genome-Wide Association Studies: Current State and Challenges.Frontiers in genetics · 2018Review
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Authors and funding
13 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Factors shaping the human intestinal microbiota range from environmental influences, like smoking and exercise, over dietary patterns and disease to the host's genetic variation. Recently, we could show in a microbiome genome-wide association study (mGWAS) targeting genetic variation influencing the β diversity of gut microbial communities, that approximately 10% of the overall gut microbiome variation can be explained by host genetics. Here, we report on the application of a new method for genotype-β-diversity association testing, the distance-based F (DBF) test. With this we identified 4 loci with genome-wide significant associations, harboring the genes CBEP4, SLC9A8, TNFSF4, and SP140, respectively. Our findings highlight the utility of the high-performance DBF test in β diversity GWAS and emphasize the important role of host genetics and immunity in shaping the human intestinal microbiota.
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