Evidence map›Paper›PMID 28816559›Full record

ArticleInhalation toxicology2017

The role of the lectin-like oxLDL receptor (LOX-1) in traffic-generated air pollution exposure-mediated alteration of the brain microvasculature in Apolipoprotein (Apo) E knockout mice.

JoAnn Lucero, Usa Suwannasual, Lindsay M Herbert, Jacob D McDonald, Amie K Lund

Open access · greenAbstract read
In one paragraph

Article in Inhalation toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 37 citations in OpenAlex.

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  17. Aging Exacerbates Neuroinflammatory Outcomes Induced by Acute Ozone Exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

JoAnn Luceroa Advanced Environmental Research Institute, Department of Biological Sciences , University of North Texas , Denton , TX , USA.
Usa Suwannasuala Advanced Environmental Research Institute, Department of Biological Sciences , University of North Texas , Denton , TX , USA.
Lindsay M Herbertb Cell Biology and Physiology , University of New Mexico , Albuquerque , NM , USA.
Jacob D McDonaldc Lovelace Biomedical and Environmental Research Institute , Albuquerque , NM , USA.
Amie K Lunda Advanced Environmental Research Institute, Department of Biological Sciences , University of North Texas , Denton , TX , USA.
University of North Texas · USMental Research Institute · USUniversity of New Mexico · US

Funding

MMP-9 Activity Mediates Vascular Effects of Inhaled Environmental Air PollutantsR00ES016586 · NIEHS · LOVELACE BIOMEDICAL & ENVIRONMENTAL RESEARCH INSTITUTE · PI LUND, AMIE KATHLEEN · 2009 to 2011
$761k
NIEHS NIH HHS R00 ES016586
6 · The paper itself

Abstract

Recent studies have shown a strong correlation between air pollution-exposure and detrimental outcomes in the central nervous system, including alterations in blood brain barrier (BBB) integrity, neuroinflammation, and neurodegeneration. However, the mechanisms mediating these pathologies have not yet been fully elucidated. We have previously reported that exposure to traffic-generated air pollution results in increased circulating oxidized low-density lipoprotein (oxLDL), associated with alterations in BBB integrity, in atherosclerotic Apolipoprotein E null (ApoE

Indexed as

Air PollutionAnimalsAntibodies, NeutralizingBrainChemokine CCL2Endothelial CellsLipid PeroxidationMaleMatrix Metalloproteinase 2Matrix Metalloproteinase 9Mice, Knockout, ApoEMicrovesselsPermeabilityReactive Oxygen SpeciesScavenger Receptors, Class EVascular Cell Adhesion Molecule-1Antibodies, NeutralizingCcl2 protein, mouseChemokine CCL2Matrix Metalloproteinase 2Matrix Metalloproteinase 9Mmp2 protein, mouseMmp9 protein, mouseOlr1 protein, mouseReactive Oxygen SpeciesScavenger Receptors, Class EVascular Cell Adhesion Molecule-1Vehicle EmissionsAir pollutionBBBinflammationLOX-1MMP-9oxLDL

Identifiers

PMID28816559
PMCPMC6732220
OpenAlexW2749503100

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.