Evidence map›Paper›PMID 28816095›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2017

New astroglial injury-defined biomarkers for neurotrauma assessment.

Julia Halford, Sean Shen, Kyohei Itamura, Jaclynn Levine, Albert C Chong, Gregg Czerwieniec, Thomas C Glenn, David A Hovda, Paul Vespa, Ross Bullock and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
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  13. BDNF: New Views of an Old Player in Traumatic Brain Injury.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Julia Halford1 Semel Institute for Neuroscience and Human Behavior, 12222 University of California , Los Angeles, CA, USA.
Sean Shen2 Department of Chemistry and Biochemistry, 12222 University of California , Los Angeles, CA, USA.
Kyohei Itamura1 Semel Institute for Neuroscience and Human Behavior, 12222 University of California , Los Angeles, CA, USA.
Jaclynn Levine1 Semel Institute for Neuroscience and Human Behavior, 12222 University of California , Los Angeles, CA, USA.
Albert C Chong1 Semel Institute for Neuroscience and Human Behavior, 12222 University of California , Los Angeles, CA, USA.
Gregg Czerwieniec2 Department of Chemistry and Biochemistry, 12222 University of California , Los Angeles, CA, USA.
Thomas C Glenn3 Department of Neurosurgery, Brain Injury Research Center, Department of Molecular and Medical Pharmacology.
David A Hovda3 Department of Neurosurgery, Brain Injury Research Center, Department of Molecular and Medical Pharmacology.
Paul Vespa4 Department of Neurology, UCLA-David Geffen School of Medicine, Los Angeles, CA, USA.
Ross Bullock5 Department of Neurological Surgery, Jackson Memorial Hospital, Miami, FL, USA.
W Dalton Dietrich6 The Miami Project to Cure Paralysis, University of Miami-Miller School of Medicine, Miami, FL, USA.
Stefania Mondello7 Department of Biomedical and Dental Sciences and Morphofunctional Imaging, 18980 University of Messina , Messina, Italy.
Joseph A Loo2 Department of Chemistry and Biochemistry, 12222 University of California , Los Angeles, CA, USA.
Ina-Beate Wanner1 Semel Institute for Neuroscience and Human Behavior, 12222 University of California , Los Angeles, CA, USA.
University of California, Los Angeles · USJackson Memorial Hospital · USUniversity of Messina · ITUniversity of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) is an expanding public health epidemic with pathophysiology that is difficult to diagnose and thus treat. TBI biomarkers should assess patients across severities and reveal pathophysiology, but currently, their kinetics and specificity are unclear. No single ideal TBI biomarker exists. We identified new candidates from a TBI CSF proteome by selecting trauma-released, astrocyte-enriched proteins including aldolase C (ALDOC), its 38kD breakdown product (BDP), brain lipid binding protein (BLBP), astrocytic phosphoprotein (PEA15), glutamine synthetase (GS) and new 18-25kD-GFAP-BDPs. Their levels increased over four orders of magnitude in severe TBI CSF. First post-injury week, ALDOC levels were markedly high and stable. Short-lived BLBP and PEA15 related to injury progression. ALDOC, BLBP and PEA15 appeared hyper-acutely and were similarly robust in severe and mild TBI blood; 25kD-GFAP-BDP appeared overnight after TBI and was rarely present after mild TBI. Using a human culture trauma model, we investigated biomarker kinetics. Wounded (mechanoporated) astrocytes released ALDOC, BLBP and PEA15 acutely. Delayed cell death corresponded with GFAP release and proteolysis into small GFAP-BDPs. Associating biomarkers with cellular injury stages produced astroglial injury-defined (AID) biomarkers that facilitate TBI assessment, as neurological deficits are rooted not only in death of CNS cells, but also in their functional compromise.

Indexed as

Apoptosis Regulatory ProteinsAstrocytesBiomarkersBrain ConcussionBrain Injuries, TraumaticCells, CulturedFatty Acid-Binding Protein 7Fructose-Bisphosphate AldolaseHumansIntracellular Signaling Peptides and ProteinsKineticsPhosphoproteinsProteomeTumor Suppressor ProteinsApoptosis Regulatory ProteinsBiomarkersFABP7 protein, humanFatty Acid-Binding Protein 7Fructose-Bisphosphate AldolaseIntracellular Signaling Peptides and ProteinsPEA15 protein, humanPhosphoproteinsProteomeTumor Suppressor ProteinsAstrocytesbrain traumacell culturecerebrospinal fluidexploratory factor analysisproteomics

Identifiers

PMID28816095
PMCPMC5624401
OpenAlexW2748412799

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.