Evidence map›Paper›PMID 28815879›Full record

ArticleHuman brain mapping2017

Calibrated imaging reveals altered grey matter metabolism related to white matter microstructure and symptom severity in multiple sclerosis.

Nicholas A Hubbard, Monroe P Turner, Minhui Ouyang, Lyndahl Himes, Binu P Thomas, Joanna L Hutchison, Shawheen Faghihahmadabadi, Scott L Davis, Jeremy F Strain, Jeffrey Spence and 8 more

Open access · greenAbstract read
In one paragraph

Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Presenilin-1 mutation position influences amyloidosis, small vessel disease, and dementia with disease stage.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  6. Article
  7. Brain aerobic glycolysis and resilience in Alzheimer disease.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  8. Article
  9. Article
  10. Altered task-induced cerebral blood flow and oxygen metabolism underlies motor impairment in multiple sclerosis.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 11 institutions in 1 country.

Nicholas A HubbardMcGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Monroe P TurnerSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas.
Minhui OuyangDepartment of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Lyndahl HimesSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas.
Binu P ThomasSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas.
Joanna L HutchisonSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas.
Shawheen FaghihahmadabadiDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.
Scott L DavisDepartment of Applied Physiology and Wellness, Southern Methodist University, Dallas, Texas.
Jeremy F StrainDepartment of Neurology, Washington University in St. Louis, St. Louis, Missouri.
Jeffrey SpenceSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas.
Daniel C KrawczykSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas.
Hao HuangDepartment of Radiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania.
Hanzhang LuDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
John HartSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas.
Teresa C FrohmanDepartment of Neurology, The University of Texas at Austin Dell Medical School, Austin, Texas.
Elliot M FrohmanDepartment of Neurology, The University of Texas at Austin Dell Medical School, Austin, Texas.
Darin T OkudaDepartment of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas.
Bart RypmaSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, Texas.
The University of Texas at Dallas · USThe University of Texas Southwestern Medical Center · USThe University of Texas at Austin · USAdvanced Imaging Research (United States) · USChildren's Hospital of Philadelphia · USJohns Hopkins Medicine · USMcGovern Institute for Brain Research · USSouthern Methodist University · USThe University of Texas Medical Branch at Galveston · USUniversity of Pennsylvania · USWashington University in St. Louis · US

Funding

The Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ROBERTS, TIMOTHY P · 2016 to 2020
$6.3M
BOLD and its discontents: age-differences in the neurophysiology of fMRI signalR01AG047972 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG, RYPMA, BART · 2015 to 2019
$1.7M
NIA NIH HHS R01 AG047972NICHD NIH HHS U54 HD086984
6 · The paper itself

Abstract

Multiple sclerosis (MS) involves damage to white matter microstructures. This damage has been related to grey matter function as measured by standard, physiologically-nonspecific neuroimaging indices (i.e., blood-oxygen-level dependent signal [BOLD]). Here, we used calibrated functional magnetic resonance imaging and diffusion tensor imaging to examine the extent to which specific, evoked grey matter physiological processes were associated with white matter diffusion in MS. Evoked changes in BOLD, cerebral blood flow (CBF), and oxygen metabolism (CMRO

Indexed as

AdultBrain MappingCalibrationCerebrovascular CirculationCohort StudiesDiffusion Tensor ImagingFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisOxygenSeverity of Illness IndexVisual CortexOxygenblood flow and metabolismcalibrated imagingdiffusion tensor imagingmultiple sclerosiswhite matter

Identifiers

PMID28815879
PMCPMC5877313
OpenAlexW2748518199

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.