Trial reportAddiction (Abingdon, England)2017
Cost-effectiveness of emergency department-initiated treatment for opioid dependence.
Trial report in Addiction (Abingdon, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00913770 (Models of Screening, Brief Intervention With a Facilitated Referral to Treatment), which is not on this map. Cited by 66 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Models of Screening, Brief Intervention With a Facilitated Referral to Treatment (SBIRT) for Opioid Patients in the Emergency Department
Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Economic Evaluations of Pharmacologic Treatment for Opioid Use Disorder: A Systematic Literature Review.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2021Pooled it
- Routes of non-traditional entry into buprenorphine treatment programs.Substance abuse treatment, prevention, and policy · 2020Pooled it
- Cost-Effectiveness of the START Hospital Addiction Consultation Service for Opioid Use Disorder Treatment.JAMA network open · 2026Trial
- Results From the POINT Pragmatic Randomized Trial: An Emergency Department-Based Peer Support Specialist Intervention to Increase Opioid Use Disorder Treatment Linkage and Reduce Recurrent Overdose.Substance use & addiction journal · 2024Trial
- Extended-Release 7-Day Injectable Buprenorphine for Patients With Minimal to Mild Opioid Withdrawal.JAMA network open · 2024Trial
- Facilitating rapid access to addiction treatment: a randomized controlled trial.Addiction science & clinical practice · 2021Trial
- Community-informed design of personalized patient-facing materials to facilitate ED-initiated treatment of opioid use disorder.PEC innovation · 2026Article
- The Financial Sustainability of Programs to Initiate Medications for Opioid Use Disorder in Emergency Department Settings.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026Article
- Microcosting implementation facilitation for emergency department-initiated buprenorphine for untreated opioid use disorder.The American journal of emergency medicine · 2025Article
- What About Nights, Weekends, and Wait Times? Adding an On-Demand Facilitated Telemedicine Buprenorphine Component to a Community-Based Peer Support Outreach Program.Substance use & addiction journal · 2025Article
- Cost-Effectiveness of Implementation Facilitation to Promote Emergency Department-Initiated Buprenorphine for Opioid Use Disorder.Annals of emergency medicine · 2025Article
- Community-involved economic evaluation and development of a cost-effectiveness calculator for two peer-driven substance use interventions.Frontiers in public health · 2025Article
- Facilitators of and barriers to buprenorphine initiation in the emergency department: a scoping review.Lancet regional health. Americas · 2024Article
- Implementation of a rural emergency department-initiated buprenorphine program in the mountain west: a study protocol.Addiction science & clinical practice · 2024Article
- Opioid Overdose After Medication for Opioid Use Disorder Initiation Following Hospitalization or ED Visit.JAMA network open · 2024Article
- Variability in Practice of Buprenorphine Treatment by Emergency Department Operational Characteristics.The western journal of emergency medicine · 2024Article
- Informing evidence-based medicine for opioid use disorder using pharmacoeconomic studies.Expert review of pharmacoeconomics & outcomes research · 2024Review
- Emergency Department Buprenorphine Quality Improvement and Emergency Physician Knowledge, Attitudes, and Self-Efficacy.The western journal of emergency medicine · 2023Article
- Economic Evaluation Design within the HEAL Prevention Cooperative.Prevention science : the official journal of the Society for Prevention Research · 2023Article
- The Cost of Universal Suicide Risk Screening for Adolescents in Emergency Departments.International journal of environmental research and public health · 2023Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsIn a recent randomized trial, patients with opioid dependence receiving brief intervention, emergency department (ED)-initiated buprenorphine and ongoing follow-up in primary care with buprenorphine (buprenorphine) were twice as likely to be engaged in addiction treatment compared with referral to community-based treatment (referral) or brief intervention and referral (brief intervention). Our aim was to evaluate the relative cost-effectiveness of these three methods of intervening on opioid dependence in the ED.
designMeasured health-care use was converted to dollar values. We considered a health-care system perspective and constructed cost-effectiveness acceptability curves that indicate the probability each treatment is cost-effective under different thresholds of willingness-to-pay for outcomes studied.
settingAn urban ED in the United States.
participantsOpioid-dependent patients aged 18 years or older. MEASUREMENTS: Self-reported 30-day assessment data were used to construct cost-effectiveness acceptability curves for patient engagement in formal addiction treatment at 30 days and the number of days illicit opioid-free in the past week.
findingsConsidering only health-care system costs, cost-effectiveness acceptability curves indicate that at all positive willingness-to-pay values, ED-initiated buprenorphine treatment was more cost-effective than brief intervention or referral. For example, at a willingness-to-pay threshold of $1000 for 30-day treatment engagement, we are 79% certain ED-initiated buprenorphine is most cost-effective compared with other studied treatments. Similar results were found for days illicit opioid-free in the past week. Results were robust to secondary analyses that included patients with missing cost data, included crime and patient time costs in the numerator, and to changes in unit price estimates.
conclusionIn the United States, emergency department-initiated buprenorphine intervention for patients with opioid dependence provides high value compared with referral to community-based treatment or combined brief intervention and referral.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.