Trial reportBritish journal of clinical pharmacology2018
Medication adherence in patients with apparent resistant hypertension: findings from the SYMPATHY trial.
Trial report in British journal of clinical pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Renal denervation for resistant hypertension.The Cochrane database of systematic reviews · 2021Pooled it
- Medication adherence in patients with apparent resistant hypertension: findings from the SYMPATHY trial.British journal of clinical pharmacology · 2018Trial
- Factors impacting chronic disease medication adherence in the UAE: a prospective cohort study, 2021-2022.Journal of comparative effectiveness research · 2025Article
- Prevalence of true resistant hypertension in those referred for uncontrolled hypertension in Malaysia: A comparison using different definitions.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Chemical adherence testing in the clinical management of hypertension: a scoping review.Frontiers in pharmacology · 2024Article
- Measurement Tools and Utility of Hair Analysis for Screening Adherence to Antihypertensive Medication.Global heart · 2023Review
- Impact of medication adherence on the efficacy of Baroreflex activation therapy.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Resistance to antihypertensive treatment and long-term risk: The Atherosclerosis Risk in Communities study.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Eligibility for Baroreflex Activation Therapy and medication adherence in patients with apparently resistant hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Article
- Antihypertensive medication adherence trends by sex and drug class: A pilot study.American heart journal plus : cardiology research and practice · 2021Article
- Is there any Hope for Monitoring Adherence in an Efficient and Feasible Way for Resistant Hypertension Diagnosis and Follow-Up?Current hypertension reports · 2020Review
- Observational
- Antithrombotic management of patients with atrial fibrillation-Dutch anticoagulant initiatives anno 2020.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2020Review
- Medication adherence-Key considerations for clinical pharmacologists.British journal of clinical pharmacology · 2020Article
- Article
- Recent advances in understanding and managing resistant/refractory hypertension.F1000Research · 2020Review
- A novel direct method to determine adherence to atorvastatin therapy in patients with coronary heart disease.British journal of clinical pharmacology · 2019Article
- Development and content validation of measures assessing adherence barriers and behaviors for use in clinical care.Research in social & administrative pharmacy : RSAP · 2019Article
- Resistant Hypertension Updated Guidelines.Current cardiology reports · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsHypertension is only controlled in approximately 35% of the patients, which could be partially due to nonadherence. Recently, bioanalytical assessment of adherence to blood pressure (BP) lowering drugs has gaining interest. Our aim was to explore possible determinants of nonadherence in treatment resistant hypertension, assessed by objective screening for antihypertensive agents in serum. The secondary aim was to study the effect of adherence on the change in BP.
methodsThis project was a substudy of SYMPATHY; an open-label randomized-controlled trial to assess the effect of renal denervation on BP 6 months after treatment compared to usual care in patients with resistant hypertension. Stored serum samples were screened for antihypertensive agents to assess adherence at baseline and 6 months after intervention, using liquid chromatography-tandem mass spectrometry. Office and 24-h BP were measured on the same day as blood was sampled. Patients and physicians were unaware of adherence measurements.
resultsNinety-eight baseline and 83 6-month samples were available for analysis. Sixty-eight percent [95% confidence interval (CI) 59-78%] of the patients was nonadherent (n = 67). For every onw pill more prescribed, 0.785 [95%CI 0.529-0.891] prescribed pill was less detected in blood. A decrease of one pill in adherence between baseline and 6 months was associated with a significant rise in office systolic BP of 4 (95%CI 0.230-8.932) mmHg.
conclusionObjective measurement of BP lowering drugs in serum, as a tool to assess adherence, showed that nonadherence was very common in patients with apparent resistant hypertension. Furthermore, the assessment results were related to (changes in) blood pressure. Our findings provide direct and objective methodology to help the physician to understand and to improve the condition of apparent resistant hypertension.
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