Evidence map›Paper›PMID 28815456›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2018

Recommendations for biomarker testing in epithelial ovarian cancer: a National Consensus Statement by the Spanish Society of Pathology and the Spanish Society of Medical Oncology.

A Oaknin, R Guarch, P Barretina, D Hardisson, A González-Martín, X Matías-Guiu, A Pérez-Fidalgo, B Vieites, I Romero, J Palacios

Erratum issuedOpen access · hybridAbstract readConsensus Statement
PubMed Publisher
In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Morphological and molecular characterization of epithelial ovarian cancer: SEOM-SEAP consensus guidelines for biomarker integration in clinical practice.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Guideline
  2. Multidisciplinary management of advanced ovarian cancer in Spain: expert recommendations for achieving maximum survival and improving patient care.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Clonal Evolution ofCells · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 2 countries.

A OakninMedical Oncology Department, Vall d'Hebron University Hospital, Vall d'Hebron Institute of Oncology (VHIO), Passeig de la Vall d'Hebron, 119-129, 08035, Barcelona, Spain. aoaknin@vhio.net.ORCID http://orcid.org/0000-0002-3592-7194
R GuarchPathology Department, Navarra University Hospital Complex, Pamplona, Spain.
P BarretinaMedical Oncology Department, ICO Girona, Doctor Josep Trueta University Hospital, Girona, Spain.
D HardissonPathology Department, La Paz University Hospital, IdiPAZ, Madrid, Spain.
A González-MartínMedical Oncology Department, MD Anderson Cancer Center, Madrid, Spain.
X Matías-GuiuPathology Department, Bellvitge University Hospital, Barcelona, CIBERONC, Barcelona, Spain.
A Pérez-FidalgoMedical Oncology Department, Clinico of Valencia University Hospital, Valencia, CIBERONC, Valencia, Spain.
B VieitesPathology Department, Virgen del Rocío University Hospital, Seville, Spain.
I RomeroMedical Oncology Department, Instituto Valenciano de Oncología, Valencia, Spain.
J PalaciosPathology Department, Ramón y Cajal University Hospital, IRICYS and Universidad de Alcalá, Madrid, CIBERONC, Ctra. Colmenar Viejo, Km 9,1, 28034, Madrid, Spain. jose.palacios@salud.madrid.org.
Bellvitge University Hospital · ESFundación Instituto Valenciano de Oncología · ESHebron University · PSHospital Clínico Universitario de Valencia · ESHospital Universitari de Girona Doctor Josep Trueta · ESHospital Universitario Virgen del Rocío · ESMD Anderson Cancer Center Madrid · ESUniversidad de Alcalá · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Because of advances in the understanding of histological and molecular characteristics in ovarian cancer, it is now possible to recognize the existence of five subtypes, which in turn has allowed a more refined therapeutic approach and better design of clinical trials. Each of these five subtypes has specific histological features and a particular biomarker expression, as well as mutations in different genes, some of which have prognostic and predictive value. CA125 and HE4 are examples of ovarian cancer biomarkers used in the diagnosis and follow-up of these malignancies. Currently, somatic or germinal mutations on BRCA1 and BRCA2 genes are the most important biomarkers in epithelial ovarian cancer having prognostic and predictive value. This article will review the histological and molecular characteristics of the five subtypes of ovarian cancer, describing the most important biomarkers and mutations that can guide in diagnosis, screening and tailored treatment strategy.

Indexed as

Biomarkers, TumorCarcinoma, Ovarian EpithelialFemaleHumansNeoplasms, Glandular and EpithelialOvarian NeoplasmsBiomarkers, TumorBRCADiagnosisMutationsPrognosisScreening

Identifiers

PMID28815456
OpenAlexW4253900660

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.