Evidence map›Paper›PMID 28815423›Full record

ArticleBiomolecular NMR assignments2017

Backbone and side-chain

Nicoleta T Ploscariu, Alvaro I Herrera, Srinivas Jayanthi, Thallapuranam K Suresh Kumar, Brian V Geisbrecht, Om Prakash

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecular NMR assignments, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nicoleta T PloscariuDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS, 66506, USA.
Alvaro I HerreraDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS, 66506, USA.
Srinivas JayanthiDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR, 72701, USA.
Thallapuranam K Suresh KumarDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR, 72701, USA.
Brian V GeisbrechtDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS, 66506, USA.
Om PrakashDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, KS, 66506, USA. omp@ksu.edu.
Kansas State University · USUniversity of Arkansas at Fayetteville · US

Funding

Novel Staphylococcal Inhibitors of Neutrophil Granule EnzymesR01GM121511 · NIGMS · KANSAS STATE UNIVERSITY · PI GEISBRECHT, BRIAN V · 2017 to 2020
$1.2M
Inhibition of the Classical & Lectin Complement Pathways by Staphylococcus aureus EapR21AI111203 · NIAID · KANSAS STATE UNIVERSITY · PI GEISBRECHT, BRIAN V · 2015 to 2016
$375k
Foundation for the National Institutes of Health AI111203National Institutes of Health GM121511NIAID NIH HHS R21 AI111203NIGMS NIH HHS R01 GM121511
6 · The paper itself

Abstract

The bacterium Staphylococcus aureus produces an array of anti-inflammatory molecules that prevent the innate immune system from recognizing it as a pathogen and clearing it from the host. In the acute phase of inflammation, our immune system relies on neutrophils to clear invading bacteria. Recently, novel classes of secreted proteins from S. aureus, including the Extracellular Adherence Protein (EAP) family (Stapels et al., Proc Natl Acad Sci USA 111:13187-13192, 2014) and the Staphylococcal Peroxidase Inhibitor (SPIN), (unpublished work) have been identified as highly selective inhibitors acting on Neutrophil Serine Proteases (NSPs) and myeloperoxidase (MPO) respectively. SPIN is a protein found only in Staphylococci, with no sequence homology to any known proteins. Solution NMR structural studies of SPIN are therefore expected to provide a deeper understanding of its interaction with MPO. In this study, we report the backbone and side-chain

Indexed as

Nuclear Magnetic Resonance, BiomolecularStaphylococcus aureusAmino Acid SequenceBacterial ProteinsEnzyme InhibitorsPeroxidaseBacterial ProteinsEnzyme InhibitorsPeroxidaseNMR assignmentStaphylococcal Peroxidase Inhibitor (SPIN)Staphylococcus aureusVirulence factor

Identifiers

PMID28815423
PMCPMC5821262
OpenAlexW2748239342

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.