ArticleBiomechanics and modeling in mechanobiology2018
Effect of aging on mechanical stresses, deformations, and hemodynamics in human femoropopliteal artery due to limb flexion.
Article in Biomechanics and modeling in mechanobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Computational Optimization of a Stent for the Femoropopliteal Artery.Annals of biomedical engineering · 2026Article
- Codify and Localize Lesions on a Coronary Acoustic Map: Scientific Rationale, Trial Design and Artificial Intelligence Algorithm Protocols.Diagnostics (Basel, Switzerland) · 2025Article
- Differential effects of demographics and risk factors on the nonlinear orthotropic mechanical properties of human femoropopliteal arteries.Biomechanics and modeling in mechanobiology · 2025Article
- Predictors of one-year clinically driven revascularization following endovascular treatment of isolated atherosclerotic popliteal artery lesions.Scientific reports · 2025Article
- Vascular Calcification Amplifies Limb Flexion-Induced Arterial Deformations and Causes Intermittent Vessel Pinching.Annals of surgery · 2025Article
- Structural and Mechanical Properties of Human Superficial Femoral and Popliteal Arteries.Annals of biomedical engineering · 2024Review
- Kneeling-induced calf ischemia: a pilot study in apparently healthy European young subjects.European journal of applied physiology · 2021Article
- Comparison of morphometric, structural, mechanical, and physiologic characteristics of human superficial femoral and popliteal arteries.Acta biomaterialia · 2021Article
- Baseline local hemodynamics as predictor of lumen remodeling at 1-year follow-up in stented superficial femoral arteries.Scientific reports · 2021Article
- Mechanical, structural, and physiologic differences in human elastic and muscular arteries of different ages: Comparison of the descending thoracic aorta to the superficial femoral artery.Acta biomaterialia · 2021Article
- Rare case of isolated true aneurysm in the superficial femoral artery treated with endovascular intervention: a case report.European heart journal. Case reports · 2020Article
- Prediction of restenosis based on hemodynamical markers in revascularized femoro-popliteal arteries during leg flexion.Biomechanics and modeling in mechanobiology · 2019Article
- In Vivo Morphological Changes of the Femoropopliteal Arteries due to Knee Flexion After Endovascular Treatment of Popliteal Aneurysm.Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists · 2019Article
- Cross-sectional pinching in human femoropopliteal arteries due to limb flexion, and stent design optimization for maximum cross-sectional opening and minimum intramural stresses.Journal of the Royal Society, Interface · 2018Article
- Nitinol Stents in the Femoropopliteal Artery: A Mechanical Perspective on Material, Design, and Performance.Annals of biomedical engineering · 2018Review
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Authors and funding
6 authors.
Funding
Abstract
Femoropopliteal artery (FPA) reconstructions are notorious for poor clinical outcomes. Mechanical and flow conditions that occur in the FPA with limb flexion are thought to play a significant role, but are poorly characterized. FPA deformations due to acute limb flexion were quantified using a human cadaver model and used to build a finite element model that simulated surrounding tissue forces associated with limb flexion-induced deformations. Strains and intramural principal mechanical stresses were determined for seven age groups. Computational fluid dynamics analysis was performed to assess hemodynamic variables. FPA shape, stresses, and hemodynamics significantly changed with age. Younger arteries assumed straighter positions in the flexed limb with less pronounced bends and more uniform stress distribution along the length of the artery. Even in the flexed limb posture, FPAs younger than 50 years of age experienced tension, while older FPAs experienced compression. Aging resulted in localization of principal mechanical stresses to the adductor hiatus and popliteal artery below the knee that are typically prone to developing vascular pathology. Maximum principal stresses in these areas increased threefold to fivefold with age with largest increase observed at the adductor hiatus. Atheroprotective wall shear stress reduced after 35 years of age, and atheroprone and oscillatory shear stresses increased after the age of 50. These data can help better understand FPA pathophysiology and can inform the design of targeted materials and devices for peripheral arterial disease treatments.
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