Evidence map›Paper›PMID 28815330›Full record

ArticleJournal of neural transmission (Vienna, Austria : 1996)2017

Homer1a protein expression in schizophrenia, bipolar disorder, and major depression.

Stefan L Leber, Ida C Llenos, Christine L Miller, Jeannette R Dulay, Johannes Haybaeck, Serge Weis

Abstract read
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In one paragraph

Article in Journal of neural transmission (Vienna, Austria : 1996), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 36 citations in OpenAlex.

  1. Pooled it
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  10. The Effects of Antipsychotics on the Synaptic Plasticity GeneInternational journal of molecular sciences · 2020
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  20. Homer2 and Alcohol: A Mutual Interaction.Frontiers in psychiatry · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Stefan L LeberDepartment of Neuropathology, Institute of Pathology, Medical University of Graz, Graz, Austria.
Ida C LlenosLaboratory of Brain Research and Neuropathology, The Stanley Medical Research Institute, Bethesda, USA.
Christine L MillerDepartment of Pediatrics, Johns Hopkins University, Baltimore, MD, USA.
Jeannette R DulayLaboratory of Brain Research and Neuropathology, The Stanley Medical Research Institute, Bethesda, USA.
Johannes HaybaeckDepartment of Neuropathology, Institute of Pathology, Medical University of Graz, Graz, Austria.
Serge WeisLaboratory of Brain Research and Neuropathology, The Stanley Medical Research Institute, Bethesda, USA. serge.weis@kepleruniklinikum.at.
Johns Hopkins University · USOtto-von-Guericke University Magdeburg · DEParacelsus Medical University · ATStanley Medical Research Institute · USUniformed Services University of the Health Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, there was growing interest in postsynaptic density proteins in the central nervous system. Of the most important candidates of this specialized region are proteins belonging to the Homer protein family. This family of scaffolding proteins is suspected to participate in the pathogenesis of a variety of diseases. The present study aims to compare Homer1a expression in the hippocampus and cingulate gyrus of patients with major psychiatric disorders including schizophrenia, bipolar disorder and major depression. Immunohistochemistry was used to analyze changes of Homer1a protein expression in the hippocampal formation and the cingulate gyrus from the respective disease groups. Glial cells of the cingulate gyrus gray matter showed decreased Homer1a levels in bipolar disorder when compared to controls. The same results were seen when comparing cingulate gyrus gray matter glial cells in bipolar disorder with major depression. Stratum oriens glial cells of the hippocampus showed decreased Homer1a levels in bipolar disorder when compared to controls and major depression. Stratum lacunosum glial cells showed decreased Homer1a levels in bipolar disorder when compared to major depression. In stratum oriens interneurons Homer1a levels were increased in all disease groups when compared to controls. Stratum lucidum axons showed decreased Homer1a levels in bipolar disorder when compared to controls. Our data demonstrate altered Homer1a levels in specific brain regions and cell types of patients suffering from schizophrenia, bipolar disorder and major depression. These findings support the role of Homer proteins as interesting candidates in neuropsychiatric pathophysiology and treatment.

Indexed as

AdultBipolar DisorderBrainFemaleHomer Scaffolding ProteinsHumansMajor Depressive DisorderMaleMiddle AgedNeurogliaNeuronsPsychiatric Status Rating ScalesSchizophreniaStatistics, NonparametricHOMER1 protein, humanHomer Scaffolding ProteinsBipolar disorderHomer1aMajor depressionSchizophrenia

Identifiers

PMID28815330
OpenAlexW2747996850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.