ArticleEuropean journal of nuclear medicine and molecular imaging2017
Prognostic value of atherosclerotic burden and coronary vascular function in patients with suspected coronary artery disease.
Article in European journal of nuclear medicine and molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis.European heart journal · 2022Pooled it
- Relationship between epicardial adipose tissue and coronary function evaluated with [13 N]NH3 PET/CT.The international journal of cardiovascular imaging · 2026Article
- Prognostic Value of Coronary Flow Capacity byCirculation. Cardiovascular imaging · 2024Article
- Impact on cardiovascular outcome of coronary revascularization-induced changes in ischemic perfusion defect and myocardial flow reserve.European journal of nuclear medicine and molecular imaging · 2024Article
- Clinical Impact of Assessment of Myocardial Flow Reserve in Identifying the Cause of Chest Discomfort.Arquivos brasileiros de cardiologia · 2024Article
- Relationship between peri-coronary inflammation and coronary vascular function in patients with suspected coronary artery disease.Frontiers in cardiovascular medicine · 2024Article
- Machine learning to predict hemodynamically significant CAD based on traditional risk factors, coronary artery calcium and epicardial fat volume.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Combined evaluation of CAC score and myocardial perfusion imaging in patients at risk of cardiovascular disease: where are we and what do the data say.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- Myocardial perfusion reserve by CZT cameras: A journey inside coronary microvascular circulation. Is it time to leave yet?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Revascularization of non-culprit lesions: A common dilemma.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prediction of outcome byJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- The addition of coronary artery calcium to myocardial perfusion: Double or nothing?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Cardiac imaging for the assessment of patients being evaluated for liver transplantation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Review
- Multimodality imaging approach to Fabry cardiomyopathy: Any role for nuclear cardiology?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Review
- Prognostic value of coronary vascular dysfunction assessed by rubidium-82 PET/CT imaging in patients with resistant hypertension without overt coronary artery disease.European journal of nuclear medicine and molecular imaging · 2021Article
- Relation between myocardial blood flow and cardiac events in diabetic patients with suspected coronary artery disease and normal myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Relationship between coronary artery calcification and myocardial ischemia on computed tomography myocardial perfusion in patients with stable chest pain.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Non-invasive assessment of temporal changes in myocardial microvascular function in persons with type 2 diabetes and healthy controls.Diabetic medicine : a journal of the British Diabetic Association · 2021Article
- The machine learning approach: Artificial intelligence is coming to support critical clinical thinking.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Coronary vascular age: An alternate means for predicting stress-induced myocardial ischemia in patients with suspected coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the prognostic value of coronary atherosclerotic burden, assessed by coronary artery calcium (CAC) score, and coronary vascular function, assessed by coronary flow reserve (CFR) in patients with suspected coronary artery disease (CAD).
methodsWe studied 436 patients undergoing hybrid
resultsFollow-up was 94% complete during a mean period of 47±15 months. During follow-up, 17 events occurred (4% cumulative event rate). Event-free survival decreased with worsening of CAC score category (p < 0.001) and in patients with reduced CFR (p < 0.005). At multivariable analysis, CAC score ≥400 (p < 0.01) and CFR (p < 0.005) were independent predictors of events. Including CFR in the prognostic model, continuous net reclassification improvement was 0.51 (0.14 in patients with events and 0.37 in those without). At classification and regression tree analysis, the initial split was on CAC score. For patients with a CAC score < 400, no further split was performed, while patients with a CAC score ≥400 were further stratified by CFR values. Decision curve analyses indicate that the model including CFR resulted in a higher net benefit across a wide range of decision threshold probabilities.
conclusionsIn patients with suspected CAD, CFR provides significant incremental risk stratification over established cardiac risk factors and CAC score for prediction of adverse cardiac events.
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