Evidence map›Paper›PMID 28815271›Full record

Trial reportThe Journal of membrane biology2017

The Prolidase Activity, Oxidative Stress, and Nitric Oxide Levels of Bladder Tissues with or Without Tumor in Patients with Bladder Cancer.

İlhan Gecit, Recep Eryılmaz, Servet Kavak, İsmail Meral, Halit Demir, Necip Pirinççi, Mustafa Güneş, Kerem Taken

Abstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in The Journal of membrane biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Current updates on the role of reactive oxygen species in bladder cancer pathogenesis and therapeutics.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2020
    Review
  10. Review
  11. The influence of diet on anti-cancer immune responsiveness.Journal of translational medicine · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

İlhan GecitDepartment of Urology, Faculty of Medicine, İnonu University, Malatya, Turkey. ilhan_gecit@hotmail.com.
Recep EryılmazDepartment of Urology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
Servet KavakDepartment of Biophysics, Faculty of Medicine, Muğla Sıtkı Koçman University, Muğla, Turkey.
İsmail MeralDepartment of Physiology, School of Medicine, Bezmialem Vakif University, İstanbul, Turkey.
Halit DemirDivision of Biochemistry, Department of Chemistry, Faculty of Science, Yuzuncu Yil University, Van, Turkey.
Necip PirinççiDepartment of Urology, Faculty of Medicine, Fırat University, Elazığ, Turkey.
Mustafa GüneşDepartment of Urology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
Kerem TakenDepartment of Urology, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey.
Van Yüzüncü Yıl Üniversitesi · TRBezmiâlem Vakıf Üniversitesi · TRFırat University · TRInonu University · TRMuğla University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study was designed to evaluate the malondialdehyde (MDA), glutathione (GSH) and nitric oxide (NO) levels, and also prolidase, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) enzyme activities in malignant and benign cancers of bladder tissue. A total of 59 patients admitted to our clinic due to microscopic or macroscopic haematuria, were prospectively included in the study. Because of some reasons (no request to participate in the study, the inability to reach, other malignancies, alcohol consumption, metabolic disease), eight patients were excluded from study. Of the 51 patients, 25 were bladder tumor patients, and 26 were patients without cancers. The bladder tissue samples were obtained from all patients under anesthesia (spinal, epidural or general) for the measurement of MDA, GSH and NO levels, and prolidase, GSH-Px and SOD enzyme activities. Among the patients with bladder cancers, 7 patients were females and 18 patients were males, with an average age of 68.4 ± 2.49. Among patients without tumors, 6 patients were females and 20 patients were males, with an average age of 58 ± 2.05. In patients with bladder tumors, the oxidants (MDA, NO, prolidase) were higher, and the antioxidants (SOD, GSH, GSH-Px) were lower than those in patients without tumors. It was concluded that the oxygen free radicals play a role in the etiology of bladder cancers similar to many other tumors and inflammatory conditions. Therefore, we assume that antioxidants may provide benefits in the prevention and treatment of bladder cancer.

Indexed as

Oxidative StressEnzymesFemaleHumansMaleNeoplasm ProteinsNitric OxidePancreatic ExtractsUrinary BladderUrinary Bladder NeoplasmsEnzymesNeoplasm ProteinsNitric OxidePancreatic ExtractsProlipaseBladderCancerNitric oxideOxidative stressStatus antioxidantsSuperoxide dismutase

Identifiers

PMID28815271
OpenAlexW2749869809

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.