Pathways to Genome-targeted Therapies in Serous Ovarian Cancer.

Joshua Axelrod, Joe Delaney

Abstract read

In one paragraph

Article in Journal of nature and science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joshua AxelrodDivision of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center, 3855 Health Sciences Drive, La Jolla, CA 39216, USA.

Joe DelaneyDivision of Gynecologic Oncology, Department of Reproductive Medicine, UCSD School of Medicine and UCSD Moores Cancer Center, 3855 Health Sciences Drive, La Jolla, CA 39216, USA.

Funding

Copy Number Alterations in Low Mutation CancerR00CA207729 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DELANEY, JOE R · 2019 to 2021

$730k

Copy Number Alterations in Low Mutation CancerK99CA207729 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DELANEY, JOE R · 2017 to 2018

$230k

NCI NIH HHS K99 CA207729NCI NIH HHS R00 CA207729

6 · The paper itself

Abstract

Genome sequencing technologies and corresponding oncology publications have generated enormous publicly available datasets for many cancer types. While this has enabled new treatments, and in some limited cases lifetime management of the disease, the treatment options for serous ovarian cancer remain dismal. This review summarizes recent advances in our understanding of ovarian cancer, with a focus on heterogeneity, functional genomics, and actionable data.

Indexed as

genomicsheterogeneityovarian cancerpathway analysistargeted therapy

Identifiers

PMID28815209

PMCPMC5555645

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.