Evidence map›Paper›PMID 28815179›Full record

ArticleBioMed research international2017

Interleukin-17 Can Induce Osteoarthritis in Rabbit Knee Joints Similar to Hulth's Method.

Zili Wang, Chenhuang Zheng, Yunbin Zhong, Jinshen He, Xu Cao, Hansong Xia, Hongliang Ba, Pei Li, Song Wu, Cheng Peng

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Effects of GH/IGF axis on bone and cartilage.Molecular and cellular endocrinology · 2021
    Review
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Zili WangDepartment of Orthopaedic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Chenhuang ZhengDepartment of Orthopaedic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Yunbin ZhongDepartment of Orthopaedic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Jinshen HeDepartment of Orthopaedic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Xu CaoDepartment of Orthopaedic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Hansong XiaDepartment of Orthopaedic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Hongliang BaDepartment of Orthopaedic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Pei LiDepartment of Orthopaedic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
Song WuDepartment of Orthopaedic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.ORCID 0000-0002-5304-3691
Cheng PengDepartment of Plastic Surgery, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.ORCID 0000-0002-7427-4085
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interleukin-17 (IL-17) is closely related to osteoarthritis (OA), but animal studies that employ IL-17 to induce OA are currently lacking. Therefore, this study evaluated the effect of IL-17 in the rabbit knee joint. The right knees served as the control group. The left knees were divided randomly into 4 groups: a Hulth group and 3 IL-17 groups (1-ng, 10-ng, and 50-ng groups). OA was induced in the Hulth group using Hulth's method. The IL-17 groups were injected with 1, 10, or 50 ng of IL-17 as indicated. Specimens were collected at 72 h, 1 week, 3 weeks, 6 weeks, and 12 weeks after surgery or the last injection. Subsequently, the following experiments were conducted: X-ray analysis, histological evaluation, and polymerase chain reaction (PCR) analysis of the mRNA expression levels of cartilage degeneration-related markers. At 12 weeks, like the Hulth group, the 10-ng and 50-ng IL-17 groups displayed typical manifestations of OA. The X-ray results, histological scores, and mRNA expression levels showed statistically significant differences between the control group and the 10-ng and 50-ng IL-17 groups. In sum, injecting 10 ng of IL-17 into the rabbit knee joint can induce OA similar to OA induced by Hulth's method.

Indexed as

AnimalsCartilage, ArticularDisease Models, AnimalHumansInterleukin-17Knee JointOsteoarthritis, KneeRabbitsInterleukin-17

Identifiers

PMID28815179
PMCPMC5549504
OpenAlexW2738105451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.