Evidence map›Paper›PMID 28815112›Full record

ArticleAMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science2017

Predicting intervention onset in the ICU with switching state space models.

Marzyeh Ghassemi, Mike Wu, Michael C Hughes, Peter Szolovits, Finale Doshi-Velez

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04713111 (Stress and Recovery in Frontline Healthcare COVID-19 Workers), which is not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04713111 nacompletednot on this mapstarted 2020, after this paper: background citation

Stress and Recovery in Frontline Healthcare COVID-19 Workers: A Feasibility Study Using Wearable and Smartphone Devices

TypeinterventionalSponsor4YouandMeRan2020 to 2020Enrolled383ConditionsCovid19, Stress, WearablesArmsLifestyle (Meditation), Lifestyle (Exercise)
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
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  9. Probabilistic Machine Learning for Healthcare.Annual review of biomedical data science · 2021
    Review
  10. Article
  11. Article
  12. Learning Predictive and Interpretable Timeseries Summaries from ICU Data.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2021
    Article
  13. Article
  14. Article
  15. Identifying Distinct, Effective Treatments for Acute Hypotension with SODA-RL: Safely Optimized Diverse Accurate Reinforcement Learning.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2020
    Article
  16. Interpretable Batch IRL to Extract Clinician Goals in ICU Hypotension Management.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2020
    Article
  17. A Review of Challenges and Opportunities in Machine Learning for Health.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2020
    Article
  18. Article
  19. The MIMIC Code Repository: enabling reproducibility in critical care research.Journal of the American Medical Informatics Association : JAMIA · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Marzyeh GhassemiMassachusetts Institute of Technology, Cambridge, MA, USA.
Mike WuYale University, New Haven, CT, USA.
Michael C HughesHarvard University, Cambridge, MA, USA.
Peter SzolovitsMassachusetts Institute of Technology, Cambridge, MA, USA.
Finale Doshi-VelezHarvard University, Cambridge, MA, USA.
Harvard University Press · USMassachusetts Institute of Technology · USYale University · US

Funding

RESEARCH TRAINING-MEDICAL INFORMATICS 90T15LM007092 · NLM · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Nils Gehlenborg · 1992 to 2026
$32.8M
NLM NIH HHS T15 LM007092
6 · The paper itself

Abstract

The impact of many intensive care unit interventions has not been fully quantified, especially in heterogeneous patient populations. We train unsupervised switching state autoregressive models on vital signs from the public MIMIC-III database to capture patient movement between physiological states. We compare our learned states to static demographics and raw vital signs in the prediction of five ICU treatments: ventilation, vasopressor administra tion, and three transfusions. We show that our learned states, when combined with demographics and raw vital signs, improve prediction for most interventions even 4 or 8 hours ahead of onset. Our results are competitive with existing work while using a substantially larger and more diverse cohort of 36,050 patients. While custom classifiers can only target a specific clinical event, our model learns physiological states which can help with many interventions. Our robust patient state representations provide a path towards evidence-driven administration of clinical interventions.

Identifiers

PMID28815112
PMCPMC5543372
OpenAlexW2785720656

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.