Evidence map›Paper›PMID 28814970›Full record

ArticleInfectious agents and cancer2017

Prevalence and characteristics of Epstein-Barr virus-associated gastric carcinomas in Portugal.

Célia Nogueira, Marta Mota, Rui Gradiz, Maria Augusta Cipriano, Francisco Caramelo, Hugo Cruz, Ana Alarcão, Francisco Castro E Sousa, Fernando Oliveira, Fernando Martinho and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infectious agents and cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 4 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 4 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Association of Helicobacter pylori and Epstein-Barr virus co-infection in gastric cancer patients: a prospective analytical study.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Detection ofCurrent issues in molecular biology · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Célia NogueiraMicrobiology, Faculty of Medicine of the University of Coimbra, 3004-504 Coimbra, Portugal.ORCID 0000-0001-8464-0045
Marta MotaMicrobiology, Faculty of Medicine of the University of Coimbra, 3004-504 Coimbra, Portugal.
Rui GradizPhysiopathology, Faculty of Medicine of the University of Coimbra, 3004-504 Coimbra, Portugal.
Maria Augusta CiprianoPathological Anatomy, University Hospitals of Coimbra, 3000-075 Coimbra, Portugal.
Francisco CarameloLaboratory of Biostatistics and Medical Informatics, IBILI, Faculty of Medicine of the University of Coimbra, 3000-548 Coimbra, Portugal.
Hugo CruzMicrobiology, Faculty of Medicine of the University of Coimbra, 3004-504 Coimbra, Portugal.
Ana AlarcãoPathology Institute, Faculty of Medicine of the University of Coimbra, 3004-504 Coimbra, Portugal.
Francisco Castro E SousaDepartment of Surgery, University Hospitals of Coimbra, 3000-075 Coimbra, Portugal.
Fernando OliveiraDepartment of Surgery, University Hospitals of Coimbra, 3000-075 Coimbra, Portugal.
Fernando MartinhoDepartment of Surgery, University Hospitals of Coimbra, 3000-075 Coimbra, Portugal.
João Moura PereiraSurgery, Regional Oncology Center of Coimbra, IPOFG, 3000-075 Coimbra, Portugal.
Paulo Figueiredo *Histopathology, Regional Oncology Center of Coimbra, IPOFG, 3000-075 Coimbra, Portugal.
Maximino Leitão *Gastroenterology, University Hospitals of Coimbra, 3000-075 Coimbra, Portugal.
Hospitais da Universidade de Coimbra · PTUniversity of Coimbra · PTInstituto Português de Oncologia de Coimbra Francisco Gentil · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGastric cancer (GC) is one of the most common malignant tumors of the digestive tract and is the third leading cause of cancer death worldwide. Epstein-Barr virus (EBV) has been associated with approximately 10% of the total cases of gastric carcinomas. No previous study has analyzed the prevalence of EBV infection in gastric cancer of the Portuguese population.

methodsIn the present study, we have analyzed 82 gastric carcinoma cases and 33 healthy individuals (control group) from Coimbra region for the presence of EBV by polymerase chain reaction (PCR) and by in situ hybridization (ISH) for EBV-encoded small RNAs (EBERs). The status of

resultsEBV was detected by PCR in 90.2% of stomach cancer cases, whereas EBERs were detected in 11%. In our series, EBV-associated gastric carcinoma (EBVaGC) were significantly associated with gender and the majority of them presented lymph node metastasis. These cases were generally graded in more advanced pTNM stages and, non-surprisingly, showed worse survival.

conclusionsThe present study shows that prevalence of EBVaGC among Portuguese population is in accordance with the worldwide prevalence. EBV infection seems to be associated to poorer prognostic and no relation to

Indexed as

Clinicopathologic featureEpstein-Barr virusGastric cancerHelicobacter pyloriPrognosis

Identifiers

PMID28814970
PMCPMC5518146
OpenAlexW2738989965

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.