ArticleNeuropsychiatric disease and treatment2017
Abnormal intrinsic functional hubs in alcohol dependence: evidence from a voxelwise degree centrality analysis.
Article in Neuropsychiatric disease and treatment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed.
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- Abnormal functional hubs in migraine patients: a resting-state MRI analysis about voxel-wise degree centrality.Journal of oral & facial pain and headache · 2024Article
- A voxel-level resting-state fMRI study on patients with alcohol use disorders based on a power spectrum slope analysis method.Frontiers in neuroscience · 2024Article
- Alterations of brain activity in patients with alcohol use disorder: a resting-state fMRI study.BMC psychiatry · 2023Article
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- Altered brain connectivity during visual stimulation in schizophrenia.Experimental brain research · 2022Article
- Molecular mechanism by which CDCP1 promotes proneural-mesenchymal transformation in primary glioblastoma.Cancer cell international · 2022Article
- Anomalies in global network connectivity associated with early recovery from alcohol dependence: A network transcranial magnetic stimulation and electroencephalography study.Addiction biology · 2022Article
- Identification of key genes with prognostic value in gastric cancer by bioinformatics analysis.Frontiers in genetics · 2022Article
- Alcohol-induced brain deficit in alcohol dependence.Frontiers in neurology · 2022Article
- Altered Functional Brain Network in Systemic Lupus Erythematosus Patients Without Overt Neuropsychiatric Symptoms Based on Resting-State Functional Magnetic Resonance Imaging and Multivariate Pattern Analysis.Frontiers in neurology · 2021Article
- A whole-brain modeling approach to identify individual and group variations in functional connectivity.Brain and behavior · 2021Article
- Abnormal degree centrality in delayed encephalopathy after carbon monoxide poisoning: a resting-state fMRI study.Neuroradiology · 2020Article
- Identification of Key Genes in Gastric Cancer by Bioinformatics Analysis.BioMed research international · 2020Article
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7 authors.
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Abstract
objectiveTo explore the abnormal intrinsic functional hubs in alcohol dependence using voxelwise degree centrality analysis approach, and their relationships with clinical features. MATERIALS AND
methodsTwenty-four male alcohol dependence subjects free of medicine (mean age, 50.21±9.62 years) and 24 age- and education-matched male healthy controls (mean age, 50.29±8.92 years) were recruited. The alcohol use disorders identification test and the severity of alcohol dependence questionnaire (SADQ) were administered to assess the severity of alcohol craving. Voxelwise degree centrality approach was used to assess the abnormal intrinsic functional hubs features in alcohol dependence. Simple linear regression analysis was performed to investigate the relationships between the clinical features and abnormal intrinsic functional hubs.
resultsCompared with healthy controls, alcohol dependence subjects exhibited significantly different degree centrality values in widespread left lateralization brain areas, including higher degree centrality values in the left precentral gyrus (BA 6), right hippocampus (BA 35, 36), and left orbitofrontal cortex (BA 11) and lower degree centrality values in the left cerebellum posterior lobe, bilateral secondary visual network (BA 18), and left precuneus (BA 7, 19). SADQ revealed a negative linear correlation with the degree centrality value in the left precentral gyrus (
conclusionThe specific abnormal intrinsic functional hubs appear to be disrupted by alcohol intoxication, which implicates at least three principal neural systems: including cerebellar, executive control, and visual cortex, which may further affect the normal motor behavior such as an explicit type of impaired driving behavior. These findings expand our understanding of the functional characteristics of alcohol dependence and may provide a new insight into the understanding of the dysfunction and pathophysiology of alcohol dependence.
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