ArticleInternational journal of nanomedicine2017
Graphene oxide and reduced graphene oxide induced neural pheochromocytoma-derived PC12 cell lines apoptosis and cell cycle alterations via the ERK signaling pathways.
Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 93 citations in OpenAlex.
- Controlled drug release and electroconductive performance of 3D printed scaffolds for neural tissue regeneration.Journal of materials science. Materials in medicine · 2026Article
- Reversibly unlocking the blood-brain barrier: A study on microtubule dynamics modulation using gold nanoparticle-modified reduced graphene oxide.Acta pharmaceutica Sinica. B · 2026Article
- Research on the Inhibition of Cancer Cell Metastasis by Graphene Oxide Suppresses the Translation of the Snail mRNA.International journal of nanomedicine · 2026Article
- Article
- Exposure to nanoscale graphene oxide deteriorates the quality of porcine oocytes via induction of oxidative stress and the apoptosis.Journal of assisted reproduction and genetics · 2025Article
- A Carbon-Based Nanomaterial with Dichotomous Effects: Antineoplastic on Oral Cancer Cells and Osteoinductive/Chondroinductive on Dental Pulp Stem Cells.Journal of functional biomaterials · 2025Article
- Evaluation the Efficacy of Reduced Graphene-based Nanofibers by Laser Irradiation for Tissue Engineering Application.World journal of plastic surgery · 2025Article
- Novel polyhydroxyalkanoate-graphene oxide composites with potential for clinical application against bacterial implant-associated infections in septic surgery.Frontiers in bioengineering and biotechnology · 2025Article
- Insights of Platinum Drug Interaction with Spinel Magnetic Nanocomposites for Targeted Anti-Cancer Effect.Cancers · 2023Article
- Tissue Engineering in Neuroscience: Applications and Perspectives.BME frontiers · 2023Review
- The mechanical, optical, and thermal properties of graphene influencing its pre-clinical use in treating neurological diseases.Frontiers in neuroscience · 2023Review
- Potential Environmental and Health Implications from the Scaled-Up Production and Disposal of Nanomaterials Used in Biosensors.Biosensors · 2022Review
- The Anticancer Efficacy of Thiourea-Mediated Reduced Graphene Oxide Nanosheets against Human Colon Cancer Cells (HT-29).Journal of functional biomaterials · 2022Article
- The Reduced Graphene Oxide (rGO) Induces Apoptosis, Autophagy and Cell Cycle Arrest in Breast Cancer Cells.International journal of molecular sciences · 2022Article
- Subchronic Graphene Exposure Reshapes Skin Cell Metabolism.Journal of proteome research · 2022Article
- Cancer-Related Intracellular Signalling Pathways Activated by DOXorubicin/Cyclodextrin-Graphene-Based Nanomaterials.Biomolecules · 2022Article
- Dependence of Graphene Oxide (GO) Toxicity on Oxidation Level, Elemental Composition, and Size.International journal of molecular sciences · 2021Article
- Modulation of Conductivity of Alginate Hydrogels Containing Reduced Graphene Oxide through the Addition of Proteins.Pharmaceutics · 2021Article
- Graphene Oxide and Reduced Graphene Oxide Nanoflakes Coated with Glycol Chitosan, Propylene Glycol Alginate, and Polydopamine: Characterization and Cytotoxicity in Human Chondrocytes.Nanomaterials (Basel, Switzerland) · 2021Article
- Graphene Family Nanomaterials in Ocular Applications: Physicochemical Properties and Toxicity.Chemical research in toxicology · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Given the novel applications of graphene materials in biomedical and electronics industry, the health hazards of these particles have attracted extensive worldwide attention. Although many studies have been performed on graphene material-induced toxic effects, toxicological data for the effect of graphene materials on the nervous system are lacking. In this study, we focused on the biological effects of graphene oxide (GO) and reduced graphene oxide (rGO) materials on PC12 cells, a type of traditional neural cell line. We found that GO and rGO exerted significant toxic effects on PC12 cells in a dose- and time-dependent manner. Moreover, apoptosis appeared to be a response to toxicity. A potent increase in the number of PC12 cells at G0/G1 phase after GO and rGO exposure was detected by cell cycle analysis. We found that phosphorylation levels of ERK signaling molecules, which are related to cell cycle regulation and apoptosis, were significantly altered after GO and rGO exposure. In conclusion, our results show that GO has more potent toxic effects than rGO and that apoptosis and cell cycle arrest are the main toxicity responses to GO and rGO treatments, which are likely due to ERK pathway regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.