ArticleInternational journal of chronic obstructive pulmonary disease2017
Platelet distribution width as a prognostic factor in patients with COPD - pilot study.
Article in International journal of chronic obstructive pulmonary disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Mean Platelet Volume and Platelet Distribution Width in Patients With Obstructive Sleep Apnea Syndrome and Concurrent Chronic Obstructive Pulmonary Disease.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis · 2018Trial
- The elevated CXCL5 levels in circulation are associated with lung function decline in COPD patients and cigarette smoking-induced mouse model of COPD.Annals of medicineTrial
- Evaluation of Platelet Distribution Width as an Early Predictor of Acute Kidney Injury in Extensive Burn Patients.Emergency medicine international · 2023Article
- Platelet count and indices as postpartum hemorrhage risk factors: a retrospective cohort study.Journal of thrombosis and haemostasis : JTH · 2021Article
- CALIPER Hematology Reference Standards (II).American journal of clinical pathology · 2020Article
- New Insights into the Implication of Mitochondrial Dysfunction in Tissue, Peripheral Blood Mononuclear Cells, and Platelets during Lung Diseases.Journal of clinical medicine · 2020Review
- Platelet distribution width: a novel prognostic marker in an internal medicine ward.Journal of community hospital internal medicine perspectives · 2019Article
- Mitochondrial functioning abnormalities observed in blood platelets of chronic smoke-exposed guinea pigs - a pilot study.International journal of chronic obstructive pulmonary diseaseArticle
- Survival in severe pulmonary hypertension due to chronic lung disease: influence of in-hospital platelet distribution width.Pulmonary circulationArticle
- Machine learning-based analysis of blood biomarker features in spastic cerebral palsy and their clinical significance.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlatelets may actively participate in inflammation in COPD. Platelet distribution width (PDW), a measure of platelets' volume heterogeneity, may increase in platelets' activation. We hypothesized that PDW may be a marker of hypercoagulation, which plays a significant role in conditions associated with worse survival of patients with COPD, eg, acute myocardial infarction and other forms of ischemic heart disease.
methodsRetrospective analysis of 79 patients. Variables were compared after grouping patients according to the upper normal limit of PDW, using Welch's
resultsTen patients presented values of PDW above 16 fL, which was the upper limit of normality for our laboratory. Compared to patients with normal PDW, they had lower forced expiratory flow between 25% and 75% of vital capacity (FEF 25-75) - 35% of reference value vs 57% (
conclusionOur analysis indicates that elevated PDW is associated with reduced survival of patients with COPD. If our data are to be confirmed, PDW may be used as an inexpensive and repeatable prognostic tool in COPD.
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