ArticleScientific reports2017
Conjugated polymers mediate effective activation of the Mammalian Ion Channel Transient Receptor Potential Vanilloid 1.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- The Impact of Physical Form on the Biocompatibility of Poly(3-hexylthiophene-2,5-diyl).Materials (Basel, Switzerland) · 2025Article
- Porous Semiconducting Polymer Nanoparticles as Intracellular Biophotonic Mediators to Modulate the Reactive Oxygen Species Balance.Nano letters · 2024Article
- Review
- Photo-Chemical Stimulation of Neurons with Organic Semiconductors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Semiconducting Polymer Nanoporous Thin Films as a Tool to Regulate Intracellular ROS Balance in Endothelial Cells.ACS applied materials & interfaces · 2023Article
- A 3D biomimetic optoelectronic scaffold repairs cranial defects.Science advances · 2023Article
- Intracellular CaFrontiers in physiology · 2023Review
- Tether-free photothermal deep-brain stimulation in freely behaving mice via wide-field illumination in the near-infrared-II window.Nature biomedical engineering · 2022Article
- Review
- Shedding Light on Thermally Induced Optocapacitance at the Organic Biointerface.The journal of physical chemistry. B · 2021Article
- Polythiophene derivatives as chemical sensors: a DFT study on the influence of side groups.Journal of molecular modeling · 2021Article
- Review
- Neuronal firing modulation by a membrane-targeted photoswitch.Nature nanotechnology · 2020Article
- Towards Novel Geneless Approaches for Therapeutic Angiogenesis.Frontiers in physiology · 2020Article
- Untangling Photofaradaic and Photocapacitive Effects in Organic Optoelectronic Stimulation Devices.Frontiers in bioengineering and biotechnology · 2020Article
- Conjugated polymers optically regulate the fate of endothelial colony-forming cells.Science advances · 2019Article
- High-Aspect-Ratio Semiconducting Polymer Pillars for 3D Cell Cultures.ACS applied materials & interfaces · 2019Article
- Use of Exogenous and Endogenous Photomediators as Efficient ROS Modulation Tools: Results and Perspectives for Therapeutic Purposes.Oxidative medicine and cellular longevity · 2019Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selective and rapid regulation of ionic channels is pivotal to the understanding of physiological processes and has a crucial impact in developing novel therapeutic strategies. Transient Receptor Potential (TRP) channels are emerging as essential cellular switches that allow animals to respond to their environment. In particular, the Vanilloid Receptor 1 (TRPV1), besides being involved in the body temperature regulation and in the response to pain, has important roles in several neuronal functions, as cytoskeleton dynamics, injured neurons regeneration, synaptic plasticity. Currently available tools to modulate TRPV1 activity suffer from limited spatial selectivity, do not allow for temporally precise control, and are usually not reversible, thus limiting their application potential. The use of optical excitation would allow for overcoming all these limitations. Here, we propose a novel strategy, based on the use of light-sensitive, conjugated polymers. We demonstrate that illumination of a polymer thin film leads to reliable, robust and temporally precise control of TRPV1 channels. Interestingly, the activation of the channel is due to the combination of two different, locally confined effects, namely the release of thermal energy from the polymer surface and the variation of the local ionic concentration at the cell/polymer interface, both mediated by the polymer photoexcitation.
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