ArticleScientific reports2017
Amygdala-centred functional connectivity affects daily cortisol concentrations: a putative link with anxiety.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 78 citations in OpenAlex.
- Stress, subjective wellbeing and self-knowledge in higher education teachers: A pilot study through bodyfulness approaches.PloS one · 2022Trial
- Midday and nadir salivary cortisol appear superior to cortisol awakening response in burnout assessment and monitoring.Scientific reports · 2018Trial
- Seeing Through Feeling: Dynamic Interplay Between Emotion and Visual Perception.Brain sciences · 2026Review
- Cerebellar Time and Relative Time: A Comparator-Based Dynamical Timing Model and its Relevance to Psychopathology and Therapies.Cerebellum (London, England) · 2026Review
- Chronic Stress and Autoimmunity: The Role of HPA Axis and Cortisol Dysregulation.International journal of molecular sciences · 2025Review
- Paralanguage as a tool for shaping stress response in Listeners: Multimodal physiological sensing study.Comprehensive psychoneuroendocrinology · 2025Article
- Cognitive reserve in subjective cognitive decline with worry: DMN-VN connectivity supports episodic memory under structural vulnerability.BMC geriatrics · 2025Article
- Modulation Effect of Physical Activity on Sleep Quality and Mental Hyperactivity in Higher-Education Students.Healthcare (Basel, Switzerland) · 2025Article
- Genetic and Environmental Influences on Anxiety Disorders: A Systematic Review of Their Onset and Development.Cureus · 2025Review
- Stress, hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis, and aggression.Metabolic brain disease · 2024Review
- The mind, brain, and body study: A protocol for examining the effects of the gut-brain-immune axis on internalizing symptoms in youth exposed to caregiving-related early adversity.Brain, behavior, & immunity - health · 2024Article
- The relationship between negative life events and cortical structural connectivity in adolescents.IBRO neuroscience reports · 2024Article
- Effects of antidepressant on FKBP51 mRNA expression and neuroendocrine hormones in patients with panic disorder.BMC psychiatry · 2024Article
- Exploring the influence of stress on aggressive behavior and sexual function: Role of neuromodulator pathways and epigenetics.Heliyon · 2024Review
- Gender-Based Heat Map Images of Campus Walking Settings: A Reflection of Lived Experience.Violence and gender · 2024Article
- In Vitro Assessment of Cortisol Release Inhibition, Bioaccessibility and Bioavailability of a Chemically CharacterizedMolecules (Basel, Switzerland) · 2024Article
- Psychophysiological Factors Moderate Amygdala-Prefrontal Connectivity Linked to Perceived Peer Victimization and Depressive Symptoms in Preadolescent Migrant Children.Depression and anxiety · 2024Article
- The Effect of Craniosacral Therapy on Blood Levels of Stress Hormones in Male Firefighter Cadets: A Randomized Clinical Trial.Behavioral sciences (Basel, Switzerland) · 2023Article
- Structural and functional improvement of amygdala sub-regions in postpartum depression after acupuncture.Frontiers in human neuroscience · 2023Article
- Regional superficial amygdala resting-state functional connectivity in adults infers childhood maltreatment severity.Psychoradiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The amygdala plays a critical role in emotion. Its functional coupling with the hippocampus and ventromedial prefrontal cortex extending to a portion of the anterior cingulate cortex (ACC) is implicated in anxiogenesis and hypothalamic-pituitary-adrenal (HPA) system regulation. However, it remains unclear how amygdala-centred functional connectivity (FC) affects anxiety and cortisol concentrations in everyday life. Here, we investigate the relationship between daily cortisol concentrations (dCOR) and amygdala-centred FC during emotional processing in forty-one healthy humans. FC analyses revealed that higher dCOR predicted strengthened amygdala-centred FC with the hippocampus and cerebellum, but inhibited FC with the supramarginal gyrus and a perigenual part of the ACC (pgACC) when processing fearful faces (vs. neutral faces). Notably, the strength of amygdala-hippocampus FC mediated the positive relationship between cortisol and anxiety, specifically when the effect of amygdala-pgACC FC, a presumptive neural indicator of emotional control, was taken into account. Individuals with diminished connectivity between the amygdala and pgACC during fear-related processing might be more vulnerable to anxiogenesis as it pertains to greater circulating cortisol levels in everyday life. Individual functional patterns of amygdala-hippocampal-pgACC connectivity might provide a key to understand the complicate link between cortisol and anxiety-related behaviors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.