Evidence map›Paper›PMID 28814788›Full record

ArticleScientific reports2017

Synthesis of Saccharumoside-B analogue with potential of antiproliferative and pro-apoptotic activities.

Srinuvasarao Rayavarapu, Nagendra Sastry Yarla, Sunanda Kumari Kadiri, Anupam Bishayee, Siddaiah Vidavalur, Ramu Tadikonda, Mahaboob Basha, Vijaya Rao Pidugu, Kaladhar S V G K Dowluru, Dhananjaya Bhadrapura Lakappa and 8 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 7 countries.

Srinuvasarao RayavarapuDepartment of Organic Chemistry, Foods, Drugs and Water, College of Science and Technology, Andhra University, Visakhapatnam, 530 003, Andhra Pradesh, India.
Nagendra Sastry YarlaDepartment of Biochemistry and Bioinformatics, School of Life Sciences, Institute of Science, GITAM University, Visakhapatnam, 530 045, Andhra Pradesh, India.
Sunanda Kumari KadiriDepartment of Microbiology, College of Science and Technology, Andhra University, Visakhapatnam, 530 003, Andhra Pradesh, India.
Anupam BishayeeDepartment of Pharmaceutical Sciences, College of Pharmacy, Larkin Health Sciences Institute, Miami, FL, 33169, USA.
Siddaiah VidavalurDepartment of Organic Chemistry, Foods, Drugs and Water, College of Science and Technology, Andhra University, Visakhapatnam, 530 003, Andhra Pradesh, India.
Ramu TadikondaDepartment of Organic Chemistry, Foods, Drugs and Water, College of Science and Technology, Andhra University, Visakhapatnam, 530 003, Andhra Pradesh, India.
Mahaboob BashaDepartment of Organic Chemistry, Foods, Drugs and Water, College of Science and Technology, Andhra University, Visakhapatnam, 530 003, Andhra Pradesh, India.
Vijaya Rao PiduguExcelra Knowledge Solutions Private Limited, NSL SEZ ARENA, IDA Uppal, Hyderabad, 500 039, Telangana, India.
Kaladhar S V G K DowluruDepartment of Microbiology and Bioinformatics, Bilaspur University, Bilaspur, 495 001, Chhattisgarh, India.
Dhananjaya Bhadrapura LakappaToxinology/Toxicology and Drug Discovery Unit, Center for Emerging Technologies, Jain Global Campus, Jain University, Kanakapura Taluk, Ramanagara, 562 112, Karnataka, India.
Mohammad A KamalEnzymoics and Novel Global Community Educational Foundation, Hebersham, NSW, Australia.
Ghulam Md AshrafKing Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Vadim V TarasovInstitute of Pharmacy and Translational Medicine, Sechenov First Moscow State Medical University, 119991, Moscow, Russia.
Vladimir N ChubarevInstitute of Pharmacy and Translational Medicine, Sechenov First Moscow State Medical University, 119991, Moscow, Russia.
Sergey G KlochkovInstitute of Physiologically Active Compounds of the Russian Academy of Sciences, Severniy Proezd, Chernogolovka, Moscow Region, 1142432, Russia.
George E BarretoDepartamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, D. C., Colombia.
Sergey O BachurinInstitute of Physiologically Active Compounds of the Russian Academy of Sciences, Severniy Proezd, Chernogolovka, Moscow Region, 1142432, Russia.
Gjumrakch AlievInstitute of Physiologically Active Compounds of the Russian Academy of Sciences, Severniy Proezd, Chernogolovka, Moscow Region, 1142432, Russia. aliev03@gmail.com.
Andhra University · INInstitute of Physiologically Active Compounds · RUSechenov University · RUJain University · INKing Abdulaziz University · SALarkin University · USNational Heart Foundation of Australia · AUPandit Sundarlal Sharma Open University · INUniversidad Autónoma de Chile · CLUniversity of Hyderabad · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new series of phenolic glycoside esters, saccharumoside-B and its analogs (9b-9n, 10) have been synthesized by the Koenigs-Knorr reaction. Antiproliferative activities of the compounds (9b-9n, 10) were evaluated on various cancer cell lines including, MCF-7 breast, HL-60 leukemia, MIA PaCa-2 pancreatic, DU145 prostate, HeLa cervical and CaCo-2 colon, as well as normal human MCF10A mammary epithelial and human peripheral blood mononuclear cells (PBMC) by MTT assay. Compounds (9b-9n, 10) exhibited considerable antiproliferative effects against cancer cells with IC

Indexed as

Antineoplastic AgentsApoptosisCell Line, TumorCell ProliferationEstersGlycosidesHumansMCF-7 CellsMolecular StructurePhenolAntineoplastic AgentsEstersGlycosidesPhenol

Identifiers

PMID28814788
PMCPMC5559490
OpenAlexW2744556160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.