ArticleScientific reports2017
The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Does the microbiome play a role in the pathogenesis of colonic diverticular disease? A systematic review.Journal of gastroenterology and hepatology · 2023Pooled it
- Microbiota of the Sigmoid Colon Mucus in Complicated Forms of Diverticular Disease.Bulletin of experimental biology and medicine · 2026Article
- Fibers and Polyphenols in Diverticular Disease: From Pathophysiology to Management.Neurogastroenterology and motility · 2025Review
- Identification of core gene-gut microbiome associations in diverticulitis patients through a two-sample mendelian randomization and bioinformatics-based investigation.Global medical genetics · 2025Article
- The Emerging Role of the Microbiota and Antibiotics in Diverticulitis Treatment.Clinics in colon and rectal surgery · 2025Review
- Metatranscriptomic analysis of colonic mucosal samples exploring the functional role of active microbial consortia in complicated diverticulitis.Microbiology spectrum · 2025Article
- Individualized care or ad hoc care: Is evidence based, personalized care for diverticulitis currently possible?Surgery open science · 2024Article
- Gut microbiome composition and metabolic activity in women with diverticulitis.Nature communications · 2024Article
- Diverticulitis is a population health problem: Lessons and gaps in strategies to implement and improve contemporary care.World journal of gastrointestinal surgery · 2023Review
- Does Alteration of the Microbiome Cause Diverticular Disease?Clinics in colon and rectal surgery · 2023Review
- Diverticular Disease and Rifaximin: An Evidence-Based Review.Antibiotics (Basel, Switzerland) · 2023Review
- Microbiota of the Colonic Diverticula in the Complicated Form of Diverticulitis: A Case Report.Life (Basel, Switzerland) · 2022Article
- Distinct changes in the colonic microbiome associated with acute diverticulitis.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2022Article
- Microbiota Composition in Diverticular Disease: Implications for Therapy.International journal of molecular sciences · 2022Review
- Otitis media susceptibility and shifts in the head and neck microbiome due toJournal of medical genetics · 2021Article
- Evaluation of molecular and genetic predisposing parameters at diverticular disease of the colon.International journal of colorectal disease · 2021Review
- Understanding the Natural History of the Disease.Seminars in colon & rectal surgery · 2021Article
- Evidence-based treatment strategies for acute diverticulitis.International journal of colorectal disease · 2021Review
- Resolution of multiply recurrent and multifocal diverticulitis after fecal microbiota transplantation.Techniques in coloproctology · 2020Article
- Observational
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
Diverticular disease is commonly associated with the older population in the United States. As individual's age, diverticulae, or herniation of the mucosa through the colonic wall, develop. In 10-25% of individuals, the diverticulae become inflamed, resulting in diverticulitis. The gut ecosystem relies on the interaction of bacteria and fungi to maintain homeostasis. Although bacterial dysbiosis has been implicated in the pathogenesis of diverticulitis, associations between the microbial ecosystem and diverticulitis remain largely unstudied. This study investigated how the cooperative network of bacteria and fungi differ between a diseased area of the sigmoid colon chronically affected by diverticulitis and adjacent non-affected tissue. To identify mucosa-associated microbes, bacterial 16S rRNA and fungal ITS sequencing were performed on chronically diseased sigmoid colon tissue (DT) and adjacent tissue (AT) from the same colonic segment. We found that Pseudomonas and Basidiomycota OTUs were associated with AT while Microbacteriaceae and Ascomycota were enriched in DT. Bipartite co-occurrence networks were constructed for each tissue type. The DT and AT networks were distinct for each tissue type, with no microbial relationships maintained after intersection merge of the groups. Our findings indicate that the microbial ecosystem distinguishes chronically diseased tissue from adjacent tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.