Evidence map›Paper›PMID 28814732›Full record

ArticleScientific reports2017

Dual Contrast - Magnetic Resonance Fingerprinting (DC-MRF): A Platform for Simultaneous Quantification of Multiple MRI Contrast Agents.

Christian E Anderson, Shannon B Donnola, Yun Jiang, Joshua Batesole, Rebecca Darrah, Mitchell L Drumm, Susann M Brady-Kalnay, Nicole F Steinmetz, Xin Yu, Mark A Griswold and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Article
  3. Reproducibility and quality assurance in MRI.Magma (New York, N.Y.) · 2025
    Article
  4. Article
  5. Utilizing TMaterials (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Multiplexed imaging in oncology.Nature biomedical engineering · 2022
    Review
  12. Magnetic resonance fingerprinting: an overview.European journal of nuclear medicine and molecular imaging · 2021
    Review
  13. Article
  14. Article
  15. Review
  16. Magnetic Resonance Fingerprinting: Implications and Opportunities for PET/MR.IEEE transactions on radiation and plasma medical sciences · 2019
    Article
  17. Article
  18. Article
  19. Article
  20. Lanthanide-Based TAngewandte Chemie (International ed. in English) · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Christian E AndersonDepartment of Radiology, Case Western Reserve University, Cleveland, OH, USA.
Shannon B DonnolaDepartment of Radiology, Case Western Reserve University, Cleveland, OH, USA.
Yun JiangDepartment of Radiology, Case Western Reserve University, Cleveland, OH, USA.
Joshua BatesoleDepartment of Radiology, Case Western Reserve University, Cleveland, OH, USA.
Rebecca DarrahFrances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
Mitchell L DrummDepartment of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
Susann M Brady-KalnayDepartment of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA.
Nicole F SteinmetzDepartment of Radiology, Case Western Reserve University, Cleveland, OH, USA.
Xin YuDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Mark A GriswoldDepartment of Radiology, Case Western Reserve University, Cleveland, OH, USA.
Chris A FlaskDepartment of Radiology, Case Western Reserve University, Cleveland, OH, USA. caf@case.edu.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
The Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI AMITABH CHAK · 2015 to 2026
$15.6M
NRSA Training CoreTL1TR002549 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI HARDING, CLIFFORD V · 2018 to 2022
$2.9M
Diagnosis and longitudinal monitoring of metastatic prostate cancer through molecular MR imaging.R01CA202814 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI STEINMETZ, NICOLE FRANZISKA · 2016 to 2020
$2.0M
(PQC5) Detecting small clusters of tumor cells with a PTPmu probeR01CA179956 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI BRADY-KALNAY, SUSANN M · 2013 to 2015
$1.9M
Development of Novel Ultra-short Echo Time - Magnetic Resonance Fingerprinting for the Assessment of Chronic Lung DiseaseF30HL136190 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI ANDERSON, CHRISTIAN EDWIN · 2017 to 2018
$82k
NCATS NIH HHS TL1 TR002549NCI NIH HHS R01 CA179956NCI NIH HHS R01 CA202814NHLBI NIH HHS F30 HL136190NIDDK NIH HHS P30 DK097948NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

Injectable Magnetic Resonance Imaging (MRI) contrast agents have been widely used to provide critical assessments of disease for both clinical and basic science imaging research studies. The scope of available MRI contrast agents has expanded over the years with the emergence of molecular imaging contrast agents specifically targeted to biological markers. Unfortunately, synergistic application of more than a single molecular contrast agent has been limited by MRI's ability to only dynamically measure a single agent at a time. In this study, a new Dual Contrast - Magnetic Resonance Fingerprinting (DC - MRF) methodology is described that can detect and independently quantify the local concentration of multiple MRI contrast agents following simultaneous administration. This "multi-color" MRI methodology provides the opportunity to monitor multiple molecular species simultaneously and provides a practical, quantitative imaging framework for the eventual clinical translation of molecular imaging contrast agents.

Indexed as

Contrast MediaGadoliniumHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingManganeseModels, TheoreticalPhantoms, ImagingReproducibility of ResultsContrast MediaGadoliniumManganese

Identifiers

PMID28814732
PMCPMC5559598

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.