ArticleScientific reports2017
Nitric Oxide regulates mouth development in amphioxus.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Evolutionary origin of the chordate nervous system revealed by amphioxus developmental trajectories.Nature ecology & evolution · 2024Article
- Nitric Oxide Function and Nitric Oxide Synthase Evolution in Aquatic Chordates.International journal of molecular sciences · 2023Review
- Evolution of the nitric oxide synthase family in vertebrates and novel insights in gill development.Proceedings. Biological sciences · 2022Article
- Expression Pattern ofGenes · 2022Article
- Novel Insights on Nitric Oxide Synthase and NO Signaling in Ascidian Metamorphosis.International journal of molecular sciences · 2022Article
- FISH for All: A Fast and Efficient FluorescentFrontiers in physiology · 2022Article
- Hedgehog signaling controls mouth opening in the amphioxus.Zoological letters · 2021Article
- Crosstalk between nitric oxide and retinoic acid pathways is essential for amphioxus pharynx development.eLife · 2021Article
- Expression Pattern of Nitric Oxide Synthase during Development of the Marine Gastropod Mollusc,Genes · 2021Article
- An Updated Staging System for Cephalochordate Development: One Table Suits Them All.Frontiers in cell and developmental biology · 2021Article
- Transphyletic conservation of nitric oxide synthase regulation in cephalochordates and tunicates.Development genes and evolution · 2020Article
- The EJC component Magoh in non-vertebrate chordates.Development genes and evolution · 2020Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The development of the mouth in animals has fascinated researchers for decades, and a recent study proposed the modern view of recurrent evolution of protostomy and deuterostomy. Here we expanded our knowledge about conserved traits of mouth formation in chordates, testing the hypothesis that nitric oxide (NO) is a potential regulator of this process. In the present work we show for the first time that NO is an essential cell signaling molecule for cephalochordate mouth formation, as previously shown for vertebrates, indicating its conserved ancestral role in chordates. The experimental decrease of NO during early amphioxus Branchiostoma lanceolatum development impaired the formation of the mouth and gill slits, demonstrating that it is a prerequisite in pharyngeal morphogenesis. Our results represent the first step in the understanding of NO physiology in non-vertebrate chordates, opening new evolutionary perspectives into the ancestral importance of NO homeostasis and acquisition of novel biological roles during evolution.
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