ArticleNature communications2017
Micromotor-enabled active drug delivery for in vivo treatment of stomach infection.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 158 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
158 citing papers in PubMed, 603 citations in OpenAlex.
- Therapeutic-scale CAR-NK microrobots with programmable swarm navigation for targeted solid tumor therapy.Science advances · 2026Article
- Task-Oriented Biomedical Microrobots: Access, Working Environment, Actuation, Body Design, Detection and Control.Micromachines · 2026Review
- Thrust Symmetry Engineering in Lithographically Defined Bubble-Propelled Micromotors via Multi-Orifice Exhaust-Port Design.ACS omega · 2026Article
- Microrobots for Precision Diagnosis and Treatment in the Digestive System: A Review of Actuation Mechanisms, Structural Design, Preclinical and Translational Applications.Micromachines · 2026Review
- Adaptive intrathecal nanorobotics in mice and nonhuman primates for navigated CNS therapy.Science advances · 2026Article
- Deployment and clearance of microrobots for localized therapy: past, present and future.National science review · 2026Review
- Magnetic/photothermal dual-driven micro/nanorobots for synergistic NO-mediated photothermal thrombolysis.Materials today. Bio · 2026Article
- Use of Micro/Nanorobots In Vivo for the Eradication of Bacterial Biofilm: A Review of Challenges and Strategies.Nanomaterials (Basel, Switzerland) · 2026Review
- Self-assembling scaffolds epigenetically reactivate and electroactively guide neuronal regeneration to restore central neural circuits.Nature communications · 2026Article
- Self-propelled platinum based magnetite Janus nanomotors prepared from PCL and PHEMA graft copolymer with physicochemical properties motility and peroxidase-like activity.Scientific reports · 2026Article
- Photocatalytic Micro/Nanomotors Functioning in the Near-Infrared Window for Biomedical Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Shape-morphing active particles with invertible effective polarizability for configurable locomotion and steering.Nature communications · 2026Article
- Phlorizin-integrated magnetic pollen micromotors for diabetes complication management.Materials today. Bio · 2025Article
- Nanotherapies based on bacterial metabolism: Mechanisms, design and application.Materials today. Bio · 2025Review
- Magnetically Controlled Microrobots for In Vivo Non-Invasive Embryo Transfer.bioRxiv : the preprint server for biology · 2025Article
- Micro/Nano-Motors for Enhanced Tumor Diagnosis and Therapy.International journal of molecular sciences · 2025Review
- Ultrasound-Induced Nitric Oxide-Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A roadmap for next-generation nanomotors.Nature nanotechnology · 2025Review
- Technology Roadmap of Micro/Nanorobots.ACS nano · 2025Review
- Advances in nanorobotics for gastrointestinal surgery: a new frontier in precision medicine and minimally invasive therapeutics.Journal of robotic surgery · 2025Review
98 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 1 institution in 1 country.
Funding
Abstract
Advances in bioinspired design principles and nanomaterials have led to tremendous progress in autonomously moving synthetic nano/micromotors with diverse functionalities in different environments. However, a significant gap remains in moving nano/micromotors from test tubes to living organisms for treating diseases with high efficacy. Here we present the first, to our knowledge, in vivo therapeutic micromotors application for active drug delivery to treat gastric bacterial infection in a mouse model using clarithromycin as a model antibiotic and Helicobacter pylori infection as a model disease. The propulsion of drug-loaded magnesium micromotors in gastric media enables effective antibiotic delivery, leading to significant bacteria burden reduction in the mouse stomach compared with passive drug carriers, with no apparent toxicity. Moreover, while the drug-loaded micromotors reach similar therapeutic efficacy as the positive control of free drug plus proton pump inhibitor, the micromotors can function without proton pump inhibitors because of their built-in proton depletion function associated with their locomotion.Nano- and micromotors have been demonstrated in vitro for a range of applications. Here the authors demonstrate the in-vivo therapeutic use of micromotors to treat H. pylori infection.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.