SynthesisPediatrics2017
Chorioamnionitis in the Development of Cerebral Palsy: A Meta-analysis and Systematic Review.
Synthesis in Pediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 4 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Maternal and neonatal outcomes following magnesium sulfate in the setting of chorioamnionitis: a meta-analysis.Archives of gynecology and obstetrics · 2024Pooled it
- Pooled it
- The impact of perinatal inflammation on the electroencephalogram in preterm infants: a systematic review.Pediatric research · 2022Pooled it
- Pooled it
- Histological chorioamnionitis and neurodevelopment at 5 years of age among infants born very preterm: EPIPAGE-2 cohort study.Archives of disease in childhood. Fetal and neonatal edition · 2026Article
- Oxytocin Modulates Microglial IL-17-Linked Inflammatory Pathways Through the IL-6/COX-2.Life (Basel, Switzerland) · 2026Article
- A sibling study of the prenatal and perinatal risks for cerebral palsy.Pediatric research · 2025Article
- Funisitis increases the risk of death or cerebral palsy in extremely preterm infants.American journal of obstetrics and gynecology · 2025Article
- Placental pathology is associated with lower quality fidgety movements in preterm infants.Pediatric research · 2025Article
- Risk factors for spastic cerebral palsy: a retrospective cross-sectional study and literature review.Italian journal of pediatrics · 2025Review
- The Effect of Tranexamic Acid on Estimated Blood Loss and Transfusion Rates in Children with Cerebral Palsy Undergoing Single-Event Multi-Level Surgery, a Retrospective Study.Children (Basel, Switzerland) · 2025Article
- Neurodevelopmental outcomes in extremely preterm infants with placental pathologic evidence of fetal inflammatroy response.Pediatric research · 2025Article
- Prenatal inflammation impairs early CD11c-positive microglia induction and delays myelination in neurodevelopmental disorders.Communications biology · 2025Article
- Distinguishing Laterality in Brain Injury in Rabbit Fetal Magnetic Resonance Imaging Using Novel Volume Rendering Techniques.Developmental neuroscience · 2025Article
- Brain injury in premature infants may be related to abnormal colonization of early gut microbiome.BMC microbiology · 2024Article
- Review
- Prenatal tobacco smoke exposure and risk for cognitive delays in infants born very premature.Scientific reports · 2024Article
- Impact of maternal infection on outcomes in extremely preterm infants.Pediatric research · 2024Article
- The Role of the Interleukin-1 Family in Complications of Prematurity.International journal of molecular sciences · 2023Review
- Establishment of a prediction model for histological chorioamnionitis and its association with outcomes of premature infants.Frontiers in pediatrics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
contextChorioamnionitis (CA) has often been linked etiologically to cerebral palsy (CP).
objectivesTo differentiate association from risk of CA in the development of CP. DATA SOURCES: PubMed, Cochrane Library, Embase, and bibliographies of original studies were searched by using the keywords (chorioamnionitis) AND ((cerebral palsy) OR brain). STUDY SELECTION: Included studies had to have: (1) controls, (2) criteria for diagnoses, and (3) neurologic follow-up. Studies were categorized based on: (1) finding incidence of CP in a CA population, or risk of CP; and (2) incidence of CA in CP or association with CP. DATA EXTRACTION: Two reviewers independently verified study inclusion and extracted data.
resultsSeventeen studies (125 256 CA patients and 5 994 722 controls) reported CP in CA. There was significantly increased CP inpreterm histologic chorioamnionitis (HCA; risk ratio [RR] = 1.34,
conclusionsThe evidence for a causal or associative role of CA in CP is weak. Preterm HCA may be a risk factor for CP, whereas CCA is not. An association with term and preterm CP was found for CCA, but only with term CP for HCA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.