ArticleScience translational medicine2017
mGlu
Abstract read
In one paragraph
Article in Science translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Movement disorders in patients with Rett syndrome: A systematic review of evidence and associated clinical considerations.Psychiatry and clinical neurosciences · 2021Pooled it
- Molecular pharmacology of mGluMolecular pharmacology · 2026Article
- Profiling metabotropic glutamate receptor 7 expression in Rett syndrome: consequences for pharmacotherapy.Neuroscience · 2026Article
- Negative allosteric modulation of mGlu7 disrupts fear memory reconsolidation and glutamatergic signaling in rat and human brain tissue.Molecular psychiatry · 2026Article
- Reciprocal regulation of the HbioRxiv : the preprint server for biology · 2025Article
- Overexpression of mGluMolecular neurobiology · 2025Article
- MECP2 Dysfunction in Rett Syndrome: Molecular Mechanisms, Multisystem Pathology, and Emerging Therapeutic Strategies.International journal of molecular sciences · 2025Review
- Profiling the Impact of mGluACS chemical neuroscience · 2025Article
- Potentiation of group III metabotropic glutamate receptors positively affects neurophysiological features in a mouse model of Rett syndrome.The Journal of pharmacology and experimental therapeutics · 2025Article
- Potentiation of the MNeurobiology of disease · 2025Article
- Pleiotropic Effects ofBiomolecules · 2025Review
- GRM7 deficiency, from excitotoxicity and neuroinflammation to neurodegeneration: Systematic review of GRM7 deficient patients.Brain, behavior, & immunity - health · 2024Review
- Activation of Metabotropic Glutamate Receptor 3 Modulates Thalamo-accumbal Transmission and Rescues Schizophrenia-Like Physiological and Behavioral Deficits.Biological psychiatry · 2024Article
- Therapeutic Potential for Metabotropic Glutamate Receptor 7 Modulators in Cognitive Disorders.Molecular pharmacology · 2024Review
- Multidimensional Analysis of a Social Behavior Identifies Regression and Phenotypic Heterogeneity in a Female Mouse Model for Rett Syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Radiosynthesis and preclinical evaluation of a carbon-11 labeled PET ligand for imaging metabotropic glutamate receptor 7.American journal of nuclear medicine and molecular imaging · 2024Article
- Differential Activity of Orthosteric Agonists and Allosteric Modulators at Metabotropic Glutamate Receptor 7.Molecular pharmacology · 2023Article
- Pharmacological Modulation of Excitotoxicity through the Combined Use of NMDA Receptor Inhibition and Group III mGlu Activation Reduces TMT-Induced Neurodegeneration in the Rat Hippocampus.International journal of molecular sciences · 2023Article
- Discovery ofACS medicinal chemistry letters · 2023Article
- GRM7 gene mutations and consequences for neurodevelopment.Pharmacology, biochemistry, and behavior · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 1 institution in 1 country.
Rocco G GogliottiDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0003-0254-7643
Rebecca K SenterDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0001-5650-1187
Nicole M FisherDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0001-6740-9618
Jeffrey AdamsDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0001-6756-5418
Rocio ZamoranoDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Adam G WalkerDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Anna L BlobaumDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0003-0349-7422
Darren W EngersDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-3633-3072
Corey R HopkinsDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0003-4958-1697
J Scott DanielsDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Carrie K JonesDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-1287-9839
Craig W LindsleyDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Zixiu XiangDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0002-1678-209X
P Jeffrey ConnDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.ORCID 0000-0003-2363-0323
Colleen M NiswenderDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA. colleen.niswender@vanderbilt.edu.ORCID 0000-0001-6009-8212
Vanderbilt University · US
Funding
The Vanderbilt Specialized Chemistry Center for Accelerated Probe DevelopmentU54MH084659 · NIMH · VANDERBILT UNIVERSITY · PI MEILER, JENS · 2008 to 2013
$24.1MTRAINING IN PHARMACOLOGICAL SCIENCEST32GM007628 · NIGMS · VANDERBILT UNIVERSITY · PI BARNETT, JOEY VICTOR, KAVALALI, EGE T · 1985 to 2022
$11.2MResearch Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1MProgram in NeurogenomicsT32MH065215 · NIMH · VANDERBILT UNIVERSITY · PI ROGER J COLBRAN · 2002 to 2026
$6.4MFUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPESR01NS031373 · NINDS · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 1993 to 2025
$6.2MFunctions of Metabotropic Glutamate Receptor SubtypesR37NS031373 · NINDS · VANDERBILT UNIVERSITY · PI CONN, P JEFFREY · 2014 to 2020
$3.5MDRUG DISCOVERY TRAINING IN AGE-RELATED DISORDERST32AG000260 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WATTERSON, DANIEL MARTIN · 1998 to 2010
$2.7MDevelopment of a Selective Metabotropic Glutamate Receptor 7 Allosteric Modulator ProbeR01MH113543 · NIMH · VANDERBILT UNIVERSITY · PI LINDSLEY, CRAIG, NISWENDER, COLLEEN M · 2017 to 2019
$1.2MMetabotropic Glutamate Receptor Regulation in MeCP2-Related DisordersR21MH102548 · NIMH · VANDERBILT UNIVERSITY · PI NISWENDER, COLLEEN M · 2014 to 2015
$431kMetabotropic Glutamate Receptor 7 as a Novel Therapeutic Target for MECP2 Duplication SyndromeF31MH113259 · NIMH · VANDERBILT UNIVERSITY · PI FISHER, NICOLE MARIE · 2017 to 2019
$88kNIA NIH HHS T32 AG000260NICHD NIH HHS U54 HD083211NIGMS NIH HHS T32 GM007628NIMH NIH HHS F31 MH113259NIMH NIH HHS R01 MH113543NIMH NIH HHS R21 MH102548NIMH NIH HHS T32 MH065215NIMH NIH HHS U54 MH084659NINDS NIH HHS R01 NS031373NINDS NIH HHS R37 NS031373
Abstract
Rett syndrome (RTT) is a neurodevelopmental disorder caused by mutations in the
Indexed as
CognitionRespirationSocial BehaviorAnimalsApneaAutopsyCA1 Region, HippocampalDisease Models, AnimalDose-Response Relationship, DrugFemaleHumansLong-Term PotentiationMaleMemoryMethyl-CpG-Binding Protein 2Micemetabotropic glutamate receptor 7Methyl-CpG-Binding Protein 2Picolinic AcidsReceptors, Metabotropic GlutamateRNA, MessengerVU0422288
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.