Evidence map›Paper›PMID 28814526›Full record

ArticleJournal of virology2017

HIV-1 Exploits a Dynamic Multi-aminoacyl-tRNA Synthetase Complex To Enhance Viral Replication.

Alice A Duchon, Corine St Gelais, Nathan Titkemeier, Joshua Hatterschide, Li Wu, Karin Musier-Forsyth

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
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  4. Structural basis for aminoacylation of cellular modified tRNAbioRxiv : the preprint server for biology · 2024
    Article
  5. AKT-dependent nuclear localization of EPRS1 activates PARP1 in breast cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  6. Insects · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Alice A DuchonDepartment of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio, USA.
Corine St GelaisCenter for Retrovirus Research, Ohio State University, Columbus, Ohio, USA.
Nathan TitkemeierDepartment of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio, USA.
Joshua HatterschideDepartment of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio, USA.
Li WuCenter for Retrovirus Research, Ohio State University, Columbus, Ohio, USA.ORCID http://orcid.org/0000-0002-5468-2487
Karin Musier-ForsythDepartment of Chemistry and Biochemistry, Ohio State University, Columbus, Ohio, USA musier@chemistry.ohio-state.edu.
The Ohio State University · US

Funding

Cellular Factors Critical for Initiation of HIV-1 Reverse TranscriptionR01GM113887 · NIGMS · OHIO STATE UNIVERSITY · PI MUSIER-FORSYTH, KARIN M · 2014 to 2019
$1.7M
Mechanisms of SAMHD1-mediated HIV-1 restriction in dendritic cellsR01AI104483 · NIAID · OHIO STATE UNIVERSITY · PI WU, LI · 2013 to 2016
$1.5M
Mechanism of Human LysRS/tRNALys Primer Recruitment and Packaging Into HIV-1F31GM119178 · NIGMS · OHIO STATE UNIVERSITY · PI DUCHON, ALICE ANN · 2015 to 2016
$69k
NIAID NIH HHS R01 AI104483NIGMS NIH HHS F31 GM119178NIGMS NIH HHS R01 GM113887
6 · The paper itself

Abstract

A hallmark of retroviruses such as human immunodeficiency virus type 1 (HIV-1) is reverse transcription of genomic RNA to DNA, a process that is primed by cellular tRNAs. HIV-1 recruits human tRNA

Indexed as

Virus AssemblyVirus ReplicationAmino Acyl-tRNA SynthetasesCytoplasmHEK293 CellsHIV-1HIV InfectionsHumansLysine-tRNA LigaseRNA, Transfer, LysAmino Acyl-tRNA SynthetasesLysine-tRNA LigaseRNA, Transfer, Lyshuman immunodeficiency viruslysyl-tRNA synthetasemultisynthetase complexnuclear localizationtRNA primer packaging

Identifiers

PMID28814526
PMCPMC5640844
OpenAlexW2747426899

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.