ArticleGut2018
Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression.
Abstract readComment
In one paragraph
Article in Gut, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 276 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
276citing papers in PubMed, 4 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
276 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- A systematic review of preclinical studies targeted toward the management of co-existing functional gastrointestinal disorders, stress, and gut dysbiosis.Naunyn-Schmiedeberg's archives of pharmacology · 2025Pooled it
- Gut dysbiosis in severe mental illness and chronic fatigue: a novel trans-diagnostic construct? A systematic review and meta-analysis.Molecular psychiatry · 2022Pooled it
- Gut permeability and osteoarthritis, towards a mechanistic understanding of the pathogenesis: a systematic review.Annals of medicine · 2021Pooled it
- Perturbations in Gut Microbiota Composition in Psychiatric Disorders: A Review and Meta-analysis.JAMA psychiatry · 2021Pooled it
- Effect of dexmedetomidine on recovery of postoperative gastrointestinal function in patients with adhesive bowel obstruction: a single-center randomized clinical trial.BMC anesthesiology · 2026Trial
- A multi-mineral intervention is associated with improved intestinal permeability in patients with ulcerative colitis: results from a pilot trial.Frontiers in medicine · 2026Trial
- Probiotics improve functional performance in patients with osteoarthritis: a randomized placebo-controlled clinical trial.European journal of nutrition · 2025Trial
- Trial
- Metabolic Status Influences Probiotic Efficacy for Depression-PRO-DEMET Randomized Clinical Trial Results.Nutrients · 2024Trial
- Effects of Flavonoid-Rich Orange Juice Intervention on Major Depressive Disorder in Young Adults: A Randomized Controlled Trial.Nutrients · 2022Trial
- Pilot Trial of Vitamin D3 and Calcifediol in Healthy Vitamin D Deficient Adults: Does It Change the Fecal Microbiome?The Journal of clinical endocrinology and metabolism · 2021Trial
- Psychophysiological Effects ofNutrients · 2021Trial
- Somatization in patients with predominant diarrhoea irritable bowel syndrome: the role of the intestinal barrier function and integrity.BMC gastroenterology · 2021Trial
- The gut-brain axis and inflammatory mediators in suicide and mental disorders with high suicide rates: a review of current evidence.Dialogues in clinical neuroscience · 2026Review
- Markers of compromised gut epithelial barrier integrity increase during the menopause transition.The Journal of clinical investigation · 2026Article
- Higher Lipopolysaccharide Levels Are Linked to Less Anhedonia and Lower Severity of Major Depressive Disorder.Brain sciences · 2026Article
- Sex differences in the associations between lifestyle, intestinal permeability and brain health in middle-aged adults.Brain, behavior, & immunity - health · 2026Article
- Article
- Single-Cell RNA Sequencing Reveals Disrupted Stromal-Epithelial Crosstalk Impairs Gut Barrier in Depression.Brain and behavior · 2026Article
- Mechanism-First Psychobiotics: Fermented Vegetables, Dairy, and Soy for Depression and Anxiety.International journal of molecular sciences · 2026Review
216 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Bruce R StevensDepartment of Physiology & Functional Genomics, University of Florida College of Medicine, Gainesville, Florida, USA.
Ruby GoelDepartment of Physiology & Functional Genomics, University of Florida College of Medicine, Gainesville, Florida, USA.
Kim SeungbumDepartment of Physiology & Functional Genomics, University of Florida College of Medicine, Gainesville, Florida, USA.
Elaine M RichardsDepartment of Physiology & Functional Genomics, University of Florida College of Medicine, Gainesville, Florida, USA.
Richard C HolbertDepartment of Psychiatry, University of Florida College of Medicine, Gainesville, Florida, USA.
Carl J PepineDivision of Cardiovascular Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.
Mohan K RaizadaDepartment of Physiology & Functional Genomics, University of Florida College of Medicine, Gainesville, Florida, USA.
Funding
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2MCVD protection mechanisms involving ACE2/Ang-(1-7) axisR01HL056921 · NHLBI · UNIVERSITY OF FLORIDA · PI RAIZADA, MOHAN K. · 1996 to 2015
$9.2MBrain Angiotensin In Hypertensive Neurons in CultureR37HL033610 · NHLBI · UNIVERSITY OF FLORIDA · PI RAIZADA, MOHAN K. · 2003 to 2012
$5.8MUFRCC for Cardiovascular Cell Therapy Research NetworkUM1HL087366 · NHLBI · UNIVERSITY OF FLORIDA · PI PEPINE, CARL J · 2012 to 2018
$4.7MBrain-Gut Microbiome-Immune Axis in HypertensionR01HL132448 · NHLBI · UNIVERSITY OF FLORIDA · PI Carl J Pepine, Steven Michael Smith · 2016 to 2026
$4.5MBRAIN ANGIOTENSIN IN HYPERTENSIVE NEURONS IN CULTURER01HL033610 · NHLBI · UNIVERSITY OF FLORIDA · PI RAIZADA, MOHAN K., SUMNERS, COLIN · 1985 to 2017
$4.3MNCATS NIH HHS UL1 TR001427NHLBI NIH HHS R01 HL033610NHLBI NIH HHS R01 HL056921NHLBI NIH HHS R01 HL132448NHLBI NIH HHS R37 HL033610NHLBI NIH HHS UM1 HL087366
Abstract
PubMed holds no abstract for this paper.
Indexed as
DepressionGastrointestinal MicrobiomeAnxietyBiomarkersCholera ToxinFatty Acid-Binding ProteinsHaptoglobinsHumansIntestinesPermeabilityProtein PrecursorsBiomarkersCholera ToxinFABP2 protein, humanFatty Acid-Binding ProteinsHaptoglobinsProtein Precursorszonulinbacterial enterotoxinbrain/gut interactionsenteric bacterial microfloraintestinal barrier functionpsychosomatic medicine
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.