Evidence map›Paper›PMID 28814475›Full record

ReviewLearning & memory (Cold Spring Harbor, N.Y.)2017

Developmental pathway genes and neural plasticity underlying emotional learning and stress-related disorders.

Marissa E Maheu, Kerry J Ressler

Open access · diamondAbstract readReview
In one paragraph

Review in Learning & memory (Cold Spring Harbor, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Methylation in OTX2 and related genes, maltreatment, and depression in children.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Marissa E MaheuDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA.
Kerry J ResslerDepartment of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA.
Harvard University · USMcLean Hospital · US

Funding

Cell Type Specific Genomic and Functional Dissection of Fear-Off Amygdala PathwaysR01MH108665 · NIMH · MCLEAN HOSPITAL · PI BOLSHAKOV, VADIM, RESSLER, KERRY J. · 2016 to 2025
$7.5M
Development of Nociceptin Receptor Agonists for Post-Traumatic Stress DisorderR01MH110441 · NIMH · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BROTHERS, SHAUN P · 2016 to 2019
$3.0M
Development, Trauma, and Genotype Effects on Biomarkers of Anxiety in ChildrenR01MH100122 · NIMH · EMORY UNIVERSITY · PI JOVANOVIC, TANJA · 2013 to 2017
$1.9M
Longitudinal DNA methylation in a non-human primate model of early-life stressR21HD088931 · NICHD · MCLEAN HOSPITAL · PI KLENGEL, TORSTEN, RESSLER, KERRY J. · 2017 to 2018
$473k
CIHRNICHD NIH HHS R21 HD088931NIMH NIH HHS R01 MH100122NIMH NIH HHS R01 MH108665NIMH NIH HHS R01 MH110441
6 · The paper itself

Abstract

The manipulation of neural plasticity as a means of intervening in the onset and progression of stress-related disorders retains its appeal for many researchers, despite our limited success in translating such interventions from the laboratory to the clinic. Given the challenges of identifying individual genetic variants that confer increased risk for illnesses like depression and post-traumatic stress disorder, some have turned their attention instead to focusing on so-called "master regulators" of plasticity that may provide a means of controlling these potentially impaired processes in psychiatric illnesses. The mammalian homolog of

Indexed as

BrainAnimalsDepressionEmotionsGene Expression Regulation, DevelopmentalHumansLearningNeuronal PlasticityStress Disorders, Post-Traumatic

Identifiers

PMID28814475
PMCPMC5580529
OpenAlexW2745793075

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.