ArticleLearning & memory (Cold Spring Harbor, N.Y.)2017
Breaking boundaries: optimizing reconsolidation-based interventions for strong and old memories.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed.
- Attenuating trauma- and cocaine-related intrusions by blocking memory reconsolidation with minocycline: protocol for a transdiagnostic randomized controlled trial.European journal of psychotraumatology · 2026Trial
- Re-encountering the phobic cue within days after a reconsolidation intervention is crucial to observe a lasting fear reduction in spider phobia.Molecular psychiatry · 2025Trial
- A high working memory load prior to memory retrieval reduces craving in non-treatment seeking problem drinkers.Psychopharmacology · 2018Trial
- Disruption of psychostimulant-associated memories by single, low dose ketamine in rats.Neuropharmacology · 2026Article
- Windows of change: Revisiting temporal and molecular dynamics of memory reconsolidation and persistence.Neuroscience and biobehavioral reviews · 2025Review
- Using computational models of learning to advance cognitive behavioral therapy.Communications psychology · 2025Review
- The Act of Measurement: The Influence of Behavioural Tests on Spider Fear and Disgust.Journal of psychopathology and behavioral assessment · 2025Article
- The clinically relevant MEK inhibitor mirdametinib combined with D-cycloserine and prediction error disrupts fear memory in PTSD models.Translational psychiatry · 2024Article
- Engrams of Fear Memory Attenuation.Advances in neurobiology · 2024Review
- Context reexposure to bolster contextual dependency of emotional episodic memory.Scientific reports · 2023Article
- Over the Edge: Extending the duration of a reconsolidation intervention for spider fear.Translational psychiatry · 2022Article
- Better, worse, or different than expected: on the role of value and identity prediction errors in fear memory reactivation.Scientific reports · 2022Article
- Interfering With Contextual Fear Memories by Post-reactivation Administration of Propranolol in Mice: A Series of Null Findings.Frontiers in behavioral neuroscience · 2022Article
- A role for amygdala endocannabinoid signaling in reconsolidation of cocaine-associated memories.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Using Extinction-Renewal to Circumvent the Memory Strength Boundary Condition in Fear Memory Reconsolidation.Brain sciences · 2021Article
- Understanding the dynamic and destiny of memories.Neuroscience and biobehavioral reviews · 2021Review
- On the theory of mental representation block. a novel perspective on learning and behavior.Communicative & integrative biology · 2021Review
- The Role of Disgust in Eating Disorders.Current psychiatry reports · 2021Review
- Placebo and Non-specific Effects in Reconsolidation-Based Treatment for Arachnophobia.Frontiers in psychiatry · 2021Article
- Is Reconsolidation a General Property of Memory?Frontiers in human neuroscience · 2021Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent research has demonstrated that consolidated memories can enter a temporary labile state after reactivation, requiring restabilization in order to persist. This process, known as reconsolidation, potentially allows for the modification and disruption of memory. Much interest in reconsolidation stems from the possibility that maladaptive memory traces-a core feature of several psychiatric conditions-could be tackled by disrupting their reconsolidation. However, research has indicated a range of supposed boundary conditions on the induction of reconsolidation. Stronger memories, often resulting from exposure to stressful conditions, or older memories, appear to be relatively resistant to undergoing reconsolidation. This may be taken as a potential stumbling block for reconsolidation-based interventions: in clinical practice, old and strong maladaptive memories are the norm rather than the exception. Yet, boundary conditions have been derived from limited experimental evidence, are not unique to reconsolidation-based interventions, and do not seem to be absolute. In this paper, we review a range of experimental studies that have aimed to disrupt old memories, or memories that were strengthened by stress manipulations, through reconsolidation. Such research highlights several techniques that could be used to optimize reconsolidation-based approaches and overcome putative boundary conditions. We supplement this review of experimental literature with a case study of a reconsolidation-based treatment of a strong and decades-old phobia for mice, further suggesting that age and strength of memory may not be insurmountable barriers. Translating findings from basic science, to human experiments, to clinical applications and back again, can potentially unlock powerful new treatments for the many people who suffer daily from anxiety disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.