Evidence map›Paper›PMID 28814471›Full record

ArticleLearning & memory (Cold Spring Harbor, N.Y.)2017

Novelty and fear conditioning induced gene expression in high and low states of anxiety.

Melanie P Donley, Jeffrey B Rosen

Open access · diamondAbstract read
In one paragraph

Article in Learning & memory (Cold Spring Harbor, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Caffeoylquinic Acids inNutrients · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Melanie P DonleyDepartment of Psychological and Brain Sciences, University of Delaware, Newark, Delaware 19716, USA.
Jeffrey B RosenDepartment of Psychological and Brain Sciences, University of Delaware, Newark, Delaware 19716, USA.ORCID 0000-0002-5933-4270
University of Delaware · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emotional states influence how stimuli are interpreted. High anxiety states in humans lead to more negative, threatening interpretations of novel information, typically accompanied by activation of the amygdala. We developed a handling protocol that induces long-lasting high and low anxiety-like states in rats to explore the role of state anxiety on brain activation during exposure to a novel environment and fear conditioning. In situ hybridization of the inducible transcription factor

Indexed as

AnimalsAnxietyBrainConditioning, ClassicalEarly Growth Response Protein 1Exploratory BehaviorFearGene Expression RegulationHandling, PsychologicalMaleRatsRats, Sprague-DawleyRNA, MessengerEarly Growth Response Protein 1Egr1 protein, ratRNA, Messenger

Identifiers

PMID28814471
PMCPMC5580523
OpenAlexW2748612645

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.