ArticleLearning & memory (Cold Spring Harbor, N.Y.)2017
On the transition from reconsolidation to extinction of contextual fear memories.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Different temporal windows for CB1 receptor involvement in contextual fear memory destabilisation in the amygdala and hippocampus.PloS one · 2019Pooled it
- Protective role of Eugenol against the destructive effects of lead on conditioned fear memory in male rats with post-traumatic stress disorder-related behavioral traits.IBRO neuroscience reports · 2024Article
- Appraising reconsolidation theory and its empirical validation.Psychonomic bulletin & review · 2023Review
- Memory destabilization during reconsolidation: a consequence of homeostatic plasticity?Learning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Using Extinction-Renewal to Circumvent the Memory Strength Boundary Condition in Fear Memory Reconsolidation.Brain sciences · 2021Article
- Understanding the dynamic and destiny of memories.Neuroscience and biobehavioral reviews · 2021Review
- Rottlerin, BDNF, and the impairment of inhibitory avoidance memory.Psychopharmacology · 2021Article
- Investigating the efficacy of the reminder-extinction procedure to disrupt contextual threat memories in humans using immersive Virtual Reality.Scientific reports · 2020Article
- Retrieval-Extinction and Relapse Prevention: Rewriting Maladaptive Drug Memories?Frontiers in behavioral neuroscience · 2020Review
- Retrieval-Dependent Mechanisms Affecting Emotional Memory Persistence: Reconsolidation, Extinction, and the Space in Between.Frontiers in behavioral neuroscience · 2020Review
- Dopaminergic D1 receptor signalling is necessary, but not sufficient for cued fear memory destabilisation.Psychopharmacology · 2019Article
- Limited replicability of drug-induced amnesia after contextual fear memory retrieval in rats.Neurobiology of learning and memory · 2019Article
- Postretrieval Relearning Strengthens Hippocampal Memories via Destabilization and Reconsolidation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Post-weaning housing conditions influence freezing during contextual fear conditioning in adult rats.Behavioural brain research · 2019Article
- 3,4-methylenedioxymethamphetamine (MDMA) impairs the extinction and reconsolidation of fear memory in rats.Physiology & behavior · 2019Article
- Temporal Flexibility of Systems Consolidation and the Synaptic Occupancy/Reset Theory (SORT): Cues About the Nature of the Engram.Frontiers in synaptic neuroscience · 2019Article
- Reconsolidation/destabilization, extinction and forgetting of fear memory as therapeutic targets for PTSD.Psychopharmacology · 2019Review
- Reconsolidation blockade for the treatment of addiction: challenges, new targets, and opportunities.Learning & memory (Cold Spring Harbor, N.Y.) · 2018Review
- Reminder duration determines threat memory modification in humans.Scientific reports · 2018Article
- A Novel Retrieval-Dependent Memory Process Revealed by the Arrest of ERK1/2 Activation in the Basolateral Amygdala.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retrieval of an associative memory can lead to different phenomena. Brief reexposure sessions tend to trigger reconsolidation, whereas more extended ones trigger extinction. In appetitive and fear cued Pavlovian memories, an intermediate "null point" period has been observed where neither process seems to be engaged. Here we investigated whether this phenomenon extends to contextual fear memory. Adult rats were subjected to a contextual fear conditioning paradigm, reexposed to the context 2 d later for 3, 5, 10, 20, or 30 min, with immediate injections of MK-801 or saline following reexposure, and tested on the following day. We observed a significant effect of MK-801 with the 3- and 30-min sessions, impairing reconsolidation and extinction, respectively. However, it did not have significant effects with 5-, 10-, or 20-min sessions, even though freezing decreased from reexposure to test. Further analyses indicated that this is not likely to be due to a variable transition point at the population level. In conclusion, the results show that in contextual fear memories there is a genuine "null point" between the parameters that induce reconsolidation and extinction, as defined by the effects of MK-801, although NMDA receptor-independent decreases in freezing can still occur in these conditions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.