ArticleNeural development2017
Septal contributions to olfactory bulb interneuron diversity in the embryonic mouse telencephalon: role of the homeobox gene Gsx2.
Article in Neural development, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 33 citations in OpenAlex.
- Olfactory bulb interneurons - The developmental timeline and targeting defined by embryonic neurogenesis.Molecular and cellular neurosciences · 2025Article
- Zic3 enables bimodal regulation of tyrosine hydroxylase expression in olfactory bulb and midbrain-derived neurons.Cell death discovery · 2025Article
- Timing Matters: Lessons From Perinatal Neurogenesis in the Olfactory Bulb.The Journal of comparative neurology · 2025Article
- Modelling a pathological GSX2 variant that selectively alters DNA binding reveals hypomorphic mouse brain defects.Disease models & mechanisms · 2025Article
- Arx revisited: involved in the development of GABAergic interneurons.Frontiers in cell and developmental biology · 2025Review
- Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte development in the mouse telencephalon.Neural development · 2023Article
- Gsx2, but not Gsx1, is necessary for early forebrain patterning and long-term survival in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Wide-ranging migration and destination of early olfactory placode-derived neurons in chick embryos.Anatomical record (Hoboken, N.J. : 2007) · 2023Article
- Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice.Development (Cambridge, England) · 2022Article
- Development of the mammalian main olfactory bulb.Development (Cambridge, England) · 2022Review
- Transcription Factor VAX1 Regulates the Regional Specification of the Subpallium Through Repressing Gsx2.Molecular neurobiology · 2021Article
- Physical interactions between Gsx2 and Ascl1 balance progenitor expansion versus neurogenesis in the mouse lateral ganglionic eminence.Development (Cambridge, England) · 2020Article
- Notch DosageFrontiers in cell and developmental biology · 2020Article
- Dlx1/2 are Central and Essential Components in the Transcriptional Code for Generating Olfactory Bulb Interneurons.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- A Pool of Postnatally Generated Interneurons Persists in an Immature Stage in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Gsx transcription factors control neuronal versus glial specification in ventricular zone progenitors of the mouse lateral ganglionic eminence.Developmental biology · 2018Article
- Cell-autonomous role of GFRα1 in the development of olfactory bulb GABAergic interneurons.Biology open · 2018Article
- Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons.Stem cell reports · 2018Article
- Neuronal Transplantation for Alzheimer's Disease and Prospects for Generating Exogenic Neurons as a Source of Cells for Implantation.Cell transplantationReview
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOlfactory bulb (OB) interneurons are known to represent diverse neuronal subtypes, which are thought to originate from a number of telencephalic regions including the embryonic dorsal lateral ganglionic eminence (dLGE) and septum. These cells migrate rostrally toward the OB, where they then radially migrate to populate different OB layers including the granule cell layer (GCL) and the outer glomerular layer (GL). Although previous studies have attempted to investigate regional contributions to OB interneuron diversity, few genetic tools have been used to address this question at embryonic time points when the earliest populations are specified.
methodsIn this study, we utilized Zic3-lacZ and Gsx2e-CIE transgenic mice as genetic fate-mapping tools to study OB interneuron contributions derived from septum and LGE, respectively. Moreover, to address the regional (i.e. septal) requirements of the homeobox gene Gsx2 for OB interneuron diversity, we conditionally inactivated Gsx2 in the septum, leaving it largely intact in the dLGE, by recombining the Gsx2 floxed allele using Olig2
resultsOur fate mapping studies demonstrated that the dLGE and septum gave rise to OB interneuron subtypes differently. Notably, the embryonic septum was found to give rise largely to the calretinin
conclusionsOur findings indicate that the septum and LGE contribute differently to OB interneuron diversity. While the dLGE provides a wide range of OB interneuron subtypes, the septum is more restricted in its contribution to the CR
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