ReviewMolecular pain
Evidence that Dry Eye Represents a Chronic Overlapping Pain Condition.
Review in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Dry eye disease and psychiatric disorders: A systematic review and meta-analysis.European journal of ophthalmology · 2022Pooled it
- Risk of Incident Dry Eye Disease Among Patients With Chronic Pain Conditions.American journal of ophthalmology · 2026Article
- Comorbidity Associations with Ocular Pain after Cataract Surgery: Overall and Sex-Stratified Analysis.AJO international · 2026Article
- Current and Developing Therapeutics for Dry Eye Disease: Targeting Ion Channels.Current issues in molecular biology · 2026Review
- A narrative literature review about alpha-lipoic acid role in dry eye and ocular surface disease.Acta ophthalmologica · 2025Review
- Corneal neuropathic pain: a review to inform clinical practice.Eye (London, England) · 2024Review
- Deciphering nociplastic pain: clinical features, risk factors and potential mechanisms.Nature reviews. Neurology · 2024Review
- Relationship between clinical parameters and quality of life in primary Sjögren's Syndrome: a prospective study.Eye (London, England) · 2023Article
- Transient Receptor Potential Channels: Important Players in Ocular Pain and Dry Eye Disease.Pharmaceutics · 2022Review
- Clinical identification of the stimulus intensity to measure temporal summation of second pain.Scientific reports · 2022Article
- Article
- Influence of Selected Ophthalmic Fluids on the Wettability and Hydration of Hydrogel and Silicone Hydrogel Contact Lenses-In Vitro Study.Materials (Basel, Switzerland) · 2022Article
- Oxytocin and secretin receptors - implications for dry eye syndrome and ocular pain.Frontiers in ophthalmology · 2022Review
- Corneal Nerve Abnormalities in Painful Dry Eye Disease Patients.Biomedicines · 2021Article
- Could contact lens dryness discomfort symptoms sometimes have a neuropathic basis?Eye and vision (London, England) · 2021Review
- Comprehensive Review and Update of Burning Eye Syndrome.Journal of patient-centered research and reviews · 2021Review
- Connections between intrinsically photosensitive retinal ganglion cells and TBI symptoms.Neurology · 2020Review
- Persistent dentoalveolar pain disorder: A putative intraoral chronic overlapping pain condition.Oral diseases · 2020Review
- Gabapentin for presumed neuropathic ocular pain.American journal of ophthalmology case reports · 2020Article
- Abnormal Spontaneous Brain Activities of Limbic-Cortical Circuits in Patients With Dry Eye Disease.Frontiers in human neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Abstract: Recent data suggest that corneal somatosensory dysfunction may be the underlying cause of severe dry eye symptoms in the absence of ocular surface pathology seen in a subset of patients diagnosed with “dry eye syndrome.” This subset of patients tends to demonstrate a unique constellation of symptoms that are persistent, more severe, and generally respond poorly to current dry eye therapies targeting inadequate or dysfunctional tears. A growing body of literature suggests that symptoms in these patients may be better characterized as neuropathic ocular pain rather than dry eye. In these patients, dry eye symptoms are often associated with numerous comorbid pain conditions and evidence of central pain processing abnormalities, where eye pain is just one of multiple overlapping peripheral manifestations. In this review, we discuss the concept and potential mechanisms of chronic overlapping pain conditions as well as evidence for considering neuropathic ocular pain as one of these overlapping pain conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.