ArticleCell reports2017
Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis.
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Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
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Who cites it
31 citing papers in PubMed, 45 citations in OpenAlex.
- Single cell multi-omics enables high-resolution identification and functional purification of human acute myeloid leukemia stem cells.bioRxiv : the preprint server for biology · 2026Article
- HOPX is required for the generation of umbilical cord blood-derived memory-like NK cells induced by three cytokines.Frontiers in immunology · 2026Article
- Single-cell transcriptome analysis defines novel molecular subtypes and reveals therapeutic implications of T/myeloid mixed-phenotype acute leukemia.Genome medicine · 2025Article
- Integrative transcriptomic and epigenomic analysis identifies BCL6B as a novel regulator of human pluripotent stem cell to endothelial differentiation.Protein & cell · 2025Article
- Review
- An in vitro model of acute horizontal basal cell activation reveals gene regulatory networks underlying the nascent activation phase.Stem cell reports · 2024Article
- Ketogenic diet does not promote triple-negative and luminal mammary tumor growth and metastasis in experimental mice.Clinical & experimental metastasis · 2024Article
- Identification and characterization of human hematopoietic mesoderm.Science China. Life sciences · 2024Article
- An integrated single-cell analysis of human adrenal cortex development.JCI insight · 2023Article
- Single-cell analysis of the postnatal dorsal V-SVZ reveals a role for Bmpr1a signaling in silencing pallial germinal activity.Science advances · 2023Article
- Next-generation plasmids for transgenesis in zebrafish and beyond.Development (Cambridge, England) · 2023Article
- Role of histamine-mediated macrophage differentiation in clearance of metastatic bacterial infection.Frontiers in immunology · 2023Article
- Integrative epigenomic and transcriptomic analysis reveals the requirement of JUNB for hematopoietic fate induction.Nature communications · 2022Article
- Review
- Increasing Complexity of Molecular Landscapes in Human Hematopoietic Stem and Progenitor Cells during Development and Aging.International journal of molecular sciences · 2022Review
- Lyl-1 regulates primitive macrophages and microglia development.Communications biology · 2021Article
- Article
- In Silico Analysis to Explore Lineage-Independent and -Dependent Transcriptional Programs Associated with the Process of Endothelial and Neural Differentiation of Human Induced Pluripotent Stem Cells.Journal of clinical medicine · 2021Article
- Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.The Journal of experimental medicine · 2021Article
- Conserved Epigenetic Regulatory Logic Infers Genes Governing Cell Identity.Cell systems · 2020Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Nathan J PalpantDepartment of Pathology, University of Washington School of Medicine, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington School of Medicine, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98109, USA. Electronic address: n.palpant@imb.uq.edu.au.
Yuliang WangDepartment of Computer Science, University of Washington School of Medicine, Seattle, WA 98109, USA.
Brandon HadlandClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Rebecca J ZaunbrecherDepartment of Bioengineering, University of Washington School of Medicine, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington School of Medicine, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98109, USA.
Meredith ReddDepartment of Bioengineering, University of Washington School of Medicine, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington School of Medicine, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98109, USA.
Daniel JonesDepartment of Computer Science, University of Washington School of Medicine, Seattle, WA 98109, USA.
Lil PabonDepartment of Pathology, University of Washington School of Medicine, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington School of Medicine, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98109, USA.
Rajan JainDepartment of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Jonathan EpsteinDepartment of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Walter L RuzzoDepartment of Computer Science, University of Washington School of Medicine, Seattle, WA 98109, USA.
Ying ZhengDepartment of Bioengineering, University of Washington School of Medicine, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington School of Medicine, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98109, USA.
Irwin BernsteinClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Adam MargolinDepartment of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.
Charles E MurryDepartment of Pathology, University of Washington School of Medicine, Seattle, WA 98109, USA; Department of Bioengineering, University of Washington School of Medicine, Seattle, WA 98109, USA; Department of Medicine/Cardiology, University of Washington School of Medicine, Seattle, WA 98109, USA; Center for Cardiovascular Biology, University of Washington School of Medicine, Seattle, WA 98109, USA; Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, WA 98109, USA. Electronic address: murry@uw.edu.
University of Washington · USFred Hutch Cancer Center · USUniversity of Pennsylvania · USOregon Health & Science University · US
Funding
Self Renewal and Differentiation of Human Embryonic Stem CellsP01GM081619 · NIGMS · UNIVERSITY OF WASHINGTON · PI MOON, RANDALL TODD · 2007 to 2017
$20.6MVascularization and Growth of Human Myocardial GraftsP01HL094374 · NHLBI · UNIVERSITY OF WASHINGTON · PI MINAMI, ELINA · 2010 to 2014
$14.5MEXPERIMENTAL PATHOLOGY OF CARDIOVASCULAR DISEASET32HL007312 · NHLBI · UNIVERSITY OF WASHINGTON · PI MAJESKY, MARK W., SCHWARTZ, STEPHEN MARK · 1985 to 2019
$11.8MExpansion of Cardiac and Hematopoietic Pregenitors by Wnt and NotchU01HL100395 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI BERNSTEIN, IRWIN D, MOON, RANDALL TODD · 2009 to 2015
$8.4MEditing Alveolar Progenitor Cells for Correction of Monogenic DiseaseU01HL134745 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI KOTTON, DARRELL N., MORRISEY, EDWARD E · 2016 to 2022
$8.3MExpansion of cardiac and hematopoietic progenitors by Wnt and NotchU01HL100405 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, JONATHAN A., MORRISEY, EDWARD E · 2009 to 2015
$8.1MCell-Based Cardiac RepairR01HL084642 · NHLBI · UNIVERSITY OF WASHINGTON · PI MURRY, CHARLES E · 2007 to 2014
$4.9MA Microfluidic Bone Marrow Niche for the Study of HematopoiesisDP2DK102258 · NIDDK · UNIVERSITY OF WASHINGTON · PI ZHENG, YING · 2013 to 2013
$2.6MInvestigating the role of Hopx in cardiac progenitor proliferationK08HL119553 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI JAIN, RAJAN · 2013 to 2017
$741kNHLBI NIH HHS K08 HL119553NHLBI NIH HHS P01 HL094374NHLBI NIH HHS R01 HL084642NHLBI NIH HHS T32 HL007312NHLBI NIH HHS U01 HL100395NHLBI NIH HHS U01 HL100405NHLBI NIH HHS U01 HL134745NIDDK NIH HHS DP2 DK102258NIGMS NIH HHS P01 GM081619
Abstract
We analyzed chromatin dynamics and transcriptional activity of human embryonic stem cell (hESC)-derived cardiac progenitor cells (CPCs) and KDR
Indexed as
Transcription, GeneticAlgorithmsbeta CateninCell DifferentiationCell LineageChromatinCRISPR-Cas SystemsEndothelial CellsFluorescent DyesGenes, ReporterHematopoiesisHomeodomain ProteinsHuman Embryonic Stem CellsHumansMesodermMyocytes, Cardiacbeta CateninChromatinCTNNB1 protein, humanFluorescent DyesHomeodomain ProteinsHOPX protein, humanTAL1 protein, humanT-Cell Acute Lymphocytic Leukemia Protein 1Tumor Suppressor Proteinscardiaccardiovascularchromatin dynamicsdifferentiationepigeneticsgenome engineeringhematopoiesishuman pluripotent stem cellWnt signaling
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