ArticleInvestigative ophthalmology & visual science2017
Subclinical Decrease in Central Inner Retinal Activity Is Associated With Myopia Development in Children.
Article in Investigative ophthalmology & visual science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Interaction of retinal electrophysiology and novel orthokeratology lens use on myopia control efficacy in children.The British journal of ophthalmology · 2025Trial
- Acute Effects of Oral Caffeine Intake on Human Global-Flash mfERG Responses: A Placebo-Controlled, Double-Masked, Balanced Crossover Study.Investigative ophthalmology & visual science · 2024Trial
- Efficacy of 0.01% atropine for myopia control in a randomized, placebo-controlled trial depends on baseline electroretinal response.Scientific reports · 2022Trial
- L- and M-cone-directed Global flash multifocal electroretinogram: conceptualization and development.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Short-Term Effects of Optically Induced and Digitally Simulated Myopic Blur on Retinal Perfusion: Insights From Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2026Article
- Orthokeratology and retinal risk: a new dimension in myopia control.Translational pediatrics · 2026Article
- Acceleration of Myopic Shifts in Refraction and Axial Elongation Begins in the Premyopia Stage.Investigative ophthalmology & visual science · 2025Article
- Reference ranges of light-adapted full-field electroretinogram and associated factors in a large cohort of healthy school-aged children and adolescents.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Is central vision (and a fovea) needed for emmetropisation?Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Measuring differences in the ERG in myopia using the RETeval device with skin electrodes.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Enhancement of the Inner Foveal Response of Young Adults with Extended-Depth-of-Focus Contact Lens for Myopia Management.Vision (Basel, Switzerland) · 2024Article
- Early Alterations in Inner-Retina Neural and Glial Saturated Responses in Lens-Induced Myopia.Translational vision science & technology · 2024Article
- Heterogenous thinning of peripapillary tissues occurs early during high myopia development in juvenile tree shrews.Experimental eye research · 2024Article
- Paediatric norms for photopic electroretinogram testing based on a large cohort of Chinese preschool children.BMJ open ophthalmology · 2024Article
- Experimentally induced myopia and myopic astigmatism alter retinal electrophysiology in chickens.Scientific reports · 2022Article
- Electroretinogram responses in myopia: a review.Documenta ophthalmologica. Advances in ophthalmology · 2022Review
- Increase in b-wave amplitude after light stimulation of the blind spot is positively correlated with the axial length of myopic individuals.Scientific reports · 2022Article
- Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes.Scientific reports · 2021Article
- Changes in fundus reflectivity during myopia development in chickens.Biomedical optics express · 2019Article
Corrections and comments
- Erratum issuedErratum.2017
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: To investigate the characteristics of retinal electrophysiological activity in relation to early myopia development in children. Methods: Fifty-six children aged 6 to 9 years with emmetropic refractive error (defined as ≥ -0.5 diopter [D] and ≤ +0.5 D) were recruited. Cycloplegic refraction, axial length, and global flash multifocal electroretinogram (MOFO mfERG) at 49% and 96% contrast levels were recorded in all children at their first visit. The refraction and axial length measurements were repeated after 1 year. The amplitudes and implicit times of the direct component (DC) and the induced component (IC) of the MOFO mfERG obtained at the initial visit were analyzed. Correlations between the MOFO mfERG parameters and changes in refractive error and axial length were investigated. Results: The mean spherical equivalent refractive error and axial length of the eyes of the children at the first visit were +0.19 ± 0.33 D and 23.14 ± 0.6 mm, respectively. After 1 year, the mean refractive error increased by -0.55 ± 0.53 D, whereas axial length increased by 0.37 ± 0.22 mm. The changes in refractive error and axial length were significantly correlated with the central IC amplitudes at 49% contrast level measured at the initial visit (ρ = 0.46, P < 0.001 and ρ = -0.34, P = 0.01, respectively). Conclusions: The prospective changes we have shown are believed to derive from central inner retina. These changes appear to precede myopia and could be a potential reference for juvenile myopia development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.