ArticlePloS one2017
Natural and artificial feeding management before weaning promote different rumen microbial colonization but not differences in gene expression levels at the rumen epithelium of newborn goats.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 57 citations in OpenAlex.
- Increasing Rumen Microbial Diversity in Goats Favours the Adaptation to High-Concentrate Diets With Minor Effects on Feed Utilization.Journal of animal physiology and animal nutrition · 2026Article
- Review
- Duration of dam contact had a long effect on calf rumen microbiota without affecting growth.Frontiers in veterinary science · 2025Article
- Maternal Transmission of Rotavirus to Calves and Comparison of Colostrum and Fecal Microbiota in Holstein and Hanwoo Cattle.Veterinary sciences · 2024Article
- Fecal Microbial Communities of Nellore and Crossbred Beef Calves Raised at Pasture.Animals : an open access journal from MDPI · 2024Article
- Altered microbiota, antimicrobial resistance genes, and functional enzyme profiles in the rumen of yak calves fed with milk replacer.Microbiology spectrum · 2024Article
- Physical, Metabolic, and Microbial Rumen Development in Goat Kids: A Review on the Challenges and Strategies of Early Weaning.Animals : an open access journal from MDPI · 2023Review
- Alternative pathways for hydrogen sink originated from the ruminal fermentation of carbohydrates: Which microorganisms are involved in lowering methane emission?Animal microbiome · 2022Review
- Long-term effects of early-life rumen microbiota modulation on dairy cow production performance and methane emissions.Frontiers in microbiology · 2022Article
- Early Weaning Stress Induces Intestinal Microbiota Disturbance, Mucosal Barrier Dysfunction and Inflammation Response Activation in Pigeon Squabs.Frontiers in microbiology · 2022Article
- Genome-Wide Identification of Reference Genes for Reverse-Transcription Quantitative PCR in Goat Rumen.Animals : an open access journal from MDPI · 2021Article
- Long-Term Effects of Dietary Supplementation with Olive Oil and Hydrogenated Vegetable Oil on the Rumen Microbiome of Dairy Cows.Microorganisms · 2021Article
- Peripheral blood mononuclear cells (PBMC) microbiome is not affected by colon microbiota in healthy goats.Animal microbiome · 2021Article
- Inoculation with rumen fluid in early life accelerates the rumen microbial development and favours the weaning process in goats.Animal microbiome · 2021Article
- Fresh Rumen Liquid Inoculant Enhances the Rumen Microbial Community Establishment in Pre-weaned Dairy Calves.Frontiers in microbiology · 2021Article
- Performance, Rumen Microbial Community and Immune Status of Goat Kids FedFrontiers in microbiology · 2021Article
- Presence of Adult Companion Goats Favors the Rumen Microbial and Functional Development in Artificially Reared Kids.Frontiers in veterinary science · 2021Article
- Chopping Roughage Length Improved Rumen Development of Weaned Calves as Revealed by Rumen Fermentation and Bacterial Community.Animals : an open access journal from MDPI · 2020Article
- Maternal influences on oral and faecal microbiota maturation in neonatal calves in beef and dairy production systems.Animal microbiome · 2020Article
- Stochasticity constrained by deterministic effects of diet and age drive rumen microbiome assembly dynamics.Nature communications · 2020Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this work was to evaluate the effect of feeding management during the first month of life (natural with the mother, NAT, or artificial with milk replacer, ART) on the rumen microbial colonization and the host innate immune response. Thirty pregnant goats carrying two fetuses were used. At birth one kid was taken immediately away from the doe and fed milk replacer (ART) while the other remained with the mother (NAT). Kids from groups received colostrum during first 2 days of life. Groups of four kids (from ART and NAT experimental groups) were slaughtered at 1, 3, 7, 14, 21 and 28 days of life. On the sampling day, after slaughtering, the rumen content was sampled and epithelial rumen tissue was collected. Pyrosequencing analyses of the bacterial community structure on samples collected at 3, 7, 14 and 28 days showed that both systems promoted significantly different colonization patterns (P = 0.001). Diversity indices increased with age and were higher in NAT feeding system. Lower mRNA abundance was detected in TLR2, TLR8 and TLR10 in days 3 and 5 compared to the other days (7, 14, 21 and 28). Only TLR5 showed a significantly different level of expression according to the feeding system, presenting higher mRNA abundances in ART kids. PGLYRP1 showed significantly higher abundance levels in days 3, 5 and 7, and then experienced a decline independently of the feeding system. These observations confirmed a highly diverse microbial colonisation from the first day of life in the undeveloped rumen, and show that the colonization pattern substantially differs between pre-ruminants reared under natural or artificial milk feeding systems. However, the rumen epithelial immune development does not differentially respond to distinct microbial colonization patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.