ArticlePloS one2017
A simple molecular mechanism explains multiple patterns of cell-size regulation.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Implications of differential size-scaling of cell-cycle regulators on cell size homeostasis.PLoS computational biology · 2023Article
- Article
- Macromolecular crowding limits growth under pressure.Nature physics · 2022Article
- A G1 Sizer Coordinates Growth and Division in the Mouse Epidermis.Current biology : CB · 2020Article
- PDE MODELS OF ADDER MECHANISMS IN CELLULAR PROLIFERATION.SIAM journal on applied mathematics · 2020Article
- Sizing up the cell cycle: systems and quantitative approaches in Chlamydomonas.Current opinion in plant biology · 2018Review
- Cell size control and gene expression homeostasis in single-cells.Current opinion in systems biology · 2018Article
- The Adder Phenomenon Emerges from Independent Control of Pre- and Post-Start Phases of the Budding Yeast Cell Cycle.Current biology : CB · 2017Article
- Details Matter: Noise and Model Structure Set the Relationship between Cell Size and Cell Cycle Timing.Frontiers in cell and developmental biology · 2017Article
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Authors and funding
3 authors.
Funding
Abstract
Increasingly accurate and massive data have recently shed light on the fundamental question of how cells maintain a stable size trajectory as they progress through the cell cycle. Microbes seem to use strategies ranging from a pure sizer, where the end of a given phase is triggered when the cell reaches a critical size, to pure adder, where the cell adds a constant size during a phase. Yet the biological origins of the observed spectrum of behavior remain elusive. We analyze a molecular size-control mechanism, based on experimental data from the yeast S. cerevisiae, that gives rise to behaviors smoothly interpolating between adder and sizer. The size-control is obtained from the accumulation of an activator protein that titrates an inhibitor protein. Strikingly, the size-control is composed of two different regimes: for small initial cell size, the size-control is a sizer, whereas for larger initial cell size, it is an imperfect adder, in agreement with recent experiments. Our model thus indicates that the adder and critical size behaviors may just be different dynamical regimes of a single simple biophysical mechanism.
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