ArticlePloS one2017
Diabetes risks and outcomes in chronic obstructive pulmonary disease patients: Two nationwide population-based retrospective cohort studies.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Chronic obstructive pulmonary disease and diabetes mellitus: a bidirectional meta-analysis of risk and comorbidity burden.Frontiers in endocrinology · 2026Pooled it
- Chronic obstructive pulmonary disease, lung function and risk of type 2 diabetes: a systematic review and meta-analysis of cohort studies.BMC pulmonary medicine · 2020Pooled it
- Frailty-stratified effectiveness of SGLT2 inhibitors versus DPP-4 inhibitors and GLP-1 receptor agonists on pulmonary outcomes in type 2 diabetes: a nationwide cohort study.EClinicalMedicine · 2025Article
- Serum Biomarkers and Gene Polymorphisms in COPD and COPD with T2DM Patients.Indian journal of clinical biochemistry : IJCB · 2025Article
- Construction and validation of a prediction model for developing type 2 diabetes mellitus in patients with chronic obstructive pulmonary disease.Frontiers in endocrinology · 2025Article
- Inflammatory markers as predictors of in-hospital mortality in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) patients with acute respiratory failure: insights from the MIMIC-IV database.Journal of thoracic disease · 2024Article
- COPD and T2DM: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Article
- Analysis of prevalence and prognosis of type 2 diabetes mellitus in patients with acute exacerbation of COPD.BMC pulmonary medicine · 2021Observational
- Effects of Pitavastatin, Atorvastatin, and Rosuvastatin on the Risk of New-Onset Diabetes Mellitus: A Single-Center Cohort Study.Biomedicines · 2020Article
- Respiratory outcomes of metformin use in patients with type 2 diabetes and chronic obstructive pulmonary disease.Scientific reports · 2020Article
- Screening for comorbidities in COPD.Breathe (Sheffield, England) · 2020Review
- Do Benefits Outweigh Risks for Corticosteroid Therapy in Acute Exacerbation of Chronic Obstructive Pulmonary Disease in People with Diabetes Mellitus?International journal of chronic obstructive pulmonary disease · 2020Review
- Incidence of type II diabetes in chronic obstructive pulmonary disease: a nested case-control study.NPJ primary care respiratory medicine · 2019Article
- Metformin use mitigates the adverse prognostic effect of diabetes mellitus in chronic obstructive pulmonary disease.Respiratory research · 2019Article
- Through the Looking Glass:Applied in vitro toxicology · 2018Review
- Prevalence and Risk Factors of ACO (Asthma-COPD Overlap) in Aboriginal People.Journal of environmental and public health · 2018Article
- The impact of comorbidities on mortality among men and women with COPD: report from the OLIN COPD study.Therapeutic advances in respiratory diseaseArticle
- Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe relationship between chronic obstructive pulmonary disease (COPD) and diabetes remains incompletely understood. This study evaluated diabetes risk and post-diabetes outcomes in COPD patients with and without exacerbations.
methodsWe identified 4671 adults newly diagnosed with COPD exacerbations and 9342 adults newly diagnosed with COPD without exacerbations during 2000-2008 using Taiwan's National Health Insurance Research Database. A comparison cohort of 18684 adults without COPD, matched by age and sex, was randomly selected from the same dataset for the control group. Diabetes events during 2000-2013 were ascertained from medical claims during the follow-up period. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of diabetes associated with COPD with or without exacerbations were calculated. We conducted another nested cohort study of 395516 patients with diabetes hospitalization during 2002-2013 and calculated adjusted odds ratios (ORs) and 95% CIs of histories of COPD and COPD exacerbations associated with adverse events after diabetes admission.
resultsDuring the follow-up period, the incidences of diabetes for patients without COPD and for patients with COPD without or with exacerbations were 3.4, 4.1 and 7.4 per 1000 person-years, respectively (P < 0.0001). Increased risk of diabetes for patients with COPD without exacerbations (HR 1.09, 95% CI 1.02-1.17) and COPD with exacerbations (HR 2.18, 95% CI 1.88-2.52) was noted. Post-diabetes pneumonia (OR 3.28, 95% CI 3.13-3.43), intensive care admission (OR 1.32, 95% CI 1.26-1.39) and mortality (OR 2.06, 95% CI 1.88-2.25) were associated with COPD exacerbations.
conclusionPrevention and intervention strategies for diabetes and post-diabetes outcomes are needed for this susceptible population.
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