Evidence map›Paper›PMID 28813008›Full record

ArticleNutrients2017

Dietary Fructose Enhances the Ability of Low Concentrations of Angiotensin II to Stimulate Proximal Tubule Na⁺ Reabsorption.

Agustin Gonzalez-Vicente, Pablo D Cabral, Nancy J Hong, Jessica Asirwatham, Nianxin Yang, Jessica M Berthiaume, Fernando P Dominici, Jeffrey L Garvin

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
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  9. Fructose in the kidney: from physiology to pathology.Kidney research and clinical practice · 2021
    Article
  10. Article
  11. Dietary fructose enhances angiotensin II-stimulated NaAmerican journal of physiology. Renal physiology · 2020
    Article
  12. Article
  13. Article
  14. Effects of reactive oxygen species on renal tubular transport.American journal of physiology. Renal physiology · 2019
    Review
  15. Article
  16. Fructose reabsorption by rat proximal tubules: role of NaAmerican journal of physiology. Renal physiology · 2019
    Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Agustin Gonzalez-VicenteDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. agustin.gonzalezvicente@case.edu.
Pablo D CabralDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. pdcabral@gmail.com.
Nancy J HongDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. nxh156@case.edu.
Jessica AsirwathamDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. jaa122@case.edu.
Nianxin YangDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. nxy66@case.edu.
Jessica M BerthiaumeDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. jessica.berthiaume@case.edu.
Fernando P DominiciFacultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina. dominici@qb.ffyb.uba.ar.
Jeffrey L GarvinDepartment of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. jlg5@case.edu.
Case Western Reserve University · USUniversidad de Buenos Aires · ARConsejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

The Role of The Proximal Nephron In Salt-Sensitive HypertensionR01HL128053 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI GARVIN, JEFFREY L. · 2016 to 2024
$4.3M
NHLBI NIH HHS R01 HL128053
6 · The paper itself

Abstract

Fructose-enriched diets cause salt-sensitive hypertension. Proximal tubules (PTs) reabsorb 70% of the water and salt filtered through the glomerulus. Angiotensin II (Ang II) regulates this process. Normally, dietary salt reduces Ang II allowing the kidney to excrete more salt, thereby preventing hypertension. We hypothesized that fructose-enriched diets enhance the ability of low concentrations of Ang II to stimulate PT transport. We measured the effects of a low concentration of Ang II (10

Indexed as

Biological TransportAngiotensin IIAnimalsBlood PressureDietary CarbohydratesFructoseGene Expression RegulationKidney Tubules, ProximalMaleRandom AllocationRatsRats, Sprague-DawleySodiumAngiotensin IIDietary CarbohydratesFructoseSodiumhypertensionkidneysalt sensitivitysodium transport

Identifiers

PMID28813008
PMCPMC5579678
OpenAlexW2749777985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.