ArticleProceedings of the National Academy of Sciences of the United States of America1987
The Thy-1 antigen exhibits rapid lateral diffusion in the plasma membrane of rodent lymphoid cells and fibroblasts.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 162 citations in OpenAlex.
- The Glycosylphosphatidylinositol Anchor: A Linchpin for Cell Surface Versatility of Trypanosomatids.Frontiers in cell and developmental biology · 2021Review
- Bridging the GAPs in plant reproduction: a comparison of plant and animal GPI-anchored proteins.Plant reproduction · 2020Review
- Direct conversion of injury-site myeloid cells to fibroblast-like cells of granulation tissue.Nature communications · 2018Article
- GPI-anchored protein organization and dynamics at the cell surface.Journal of lipid research · 2016Review
- Live fibroblast harvest reveals surface marker shift in vitro.Tissue engineering. Part C, Methods · 2015Article
- From fast fluorescence imaging to molecular diffusion law on live cell membranes in a commercial microscope.Journal of visualized experiments : JoVE · 2014Article
- Astrocytic αVβ3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering Thy-1.PloS one · 2012Article
- ICAM-1 mediates surface contact between neutrophils and keratocytes following corneal epithelial abrasion in the mouse.Experimental eye research · 2010Article
- A complex of three related membrane proteins is conserved on malarial merozoites.Molecular and biochemical parasitology · 2009Article
- Expression of excess receptors and negative feedback control of signal pathways are required for rapid activation and prompt cessation of signal transduction.Cell communication and signaling : CCS · 2009Article
- Both MHC class II and its GPI-anchored form undergo hop diffusion as observed by single-molecule tracking.Biophysical journal · 2008Article
- Ras diffusion is sensitive to plasma membrane viscosity.Biophysical journal · 2005Article
- Dynamics of putative raft-associated proteins at the cell surface.The Journal of cell biology · 2004Article
- Insulin stimulates the release of the glycosyl phosphatidylinositol-anchored membrane dipeptidase from 3T3-L1 adipocytes through the action of a phospholipase C.The Biochemical journal · 1997Article
- Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains.The Journal of cell biology · 1996Article
- Endocytosis of chimeric influenza virus hemagglutinin proteins that lack a cytoplasmic recognition feature for coated pits.The Journal of cell biology · 1996Article
- Replacement of the phospholipid-anchor in the contact site A glycoprotein of D. discoideum by a transmembrane region does not impede cell adhesion but reduces residence time on the cell surface.The Journal of cell biology · 1994Article
- Glycosyl phosphatidylinositol--anchored T-cadherin mediates calcium-dependent, homophilic cell adhesion.The Journal of cell biology · 1992Article
- Spontaneous incorporation of the glycosyl-phosphatidylinositol-linked protein Thy-1 into cell membranes.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Expression of unique sets of GPI-linked proteins by different primary neurons in vitro.The Journal of cell biology · 1992Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Thy-1 is a plasma membrane protein, but its primary structure lacks the typical membrane-spanning sequence. Recent studies revealed that a glycophospholipid is covalently bound to the carboxyl terminus, suggesting that the protein is integrated into the plasma membrane by this lipid moiety. Lateral diffusion of Thy-1 was measured in mouse thymocytes, lymphoma cells, and fibroblasts by the fluorescence recovery after photobleaching technique. Thy-1 was labeled with rhodamine-conjugated anti-Thy-1 monoclonal antibodies. Diffusion coefficients of 2-4 X 10(-9) cm2/sec were obtained for the antigen-antibody complex in all the cell types. About 50% of the Thy-1 was mobile. The diffusion coefficient for the mobile fraction of Thy-1 is considerably larger than the diffusion coefficients of many other plasma membrane proteins. Rather, the diffusion coefficient of Thy-1 is similar to those of lipid analogs embedded in the same membrane, providing strong support for the suggested lipid anchoring of this antigen.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.