ArticleNature ecology & evolution2017
Perceptive costs of reproduction drive ageing and physiology in male Drosophila.
Article in Nature ecology & evolution, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Ageing effects of social environments in 'non-social' insects.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Pooled it
- Mistranslation protects against lifespan reduction due to mating in Drosophila melanogaster females.G3 (Bethesda, Md.) · 2026Article
- Perception and Longevity Control in Invertebrate Model Organisms-A Mini-Review of Recent Advances.Biomolecules · 2025Review
- Exposure to female olfactory cues hastens reproductive ageing and increases mortality when mating in male mice.Proceedings. Biological sciences · 2024Article
- The neuropeptide drosulfakinin enhances choosiness and protects males from the aging effects of social perception.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Sociosexual Exposure Has Opposing Effects on Male and Female Actuarial Senescence in the Fruit Fly Drosophila melanogaster.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Sensory detection of female olfactory cues as a central regulator of energy metabolism and body weight in male mice.iScience · 2023Article
- Light modulatesAging · 2023Article
- Article
- Does perception of female cues modulate male short-term fitness components inEcology and evolution · 2022Article
- Separating the effects of paternal age and mating history: Evidence for sex-specific paternal effect in eastern mosquitofish.Evolution; international journal of organic evolution · 2022Article
- Genetic and social contributions to sex differences in lifespan in Drosophila serrata.Journal of evolutionary biology · 2022Article
- Sex-specific aging in animals: Perspective and future directions.Aging cell · 2022Review
- The Biology of Aging in Insects: FromAnnual review of entomology · 2022Review
- Patterns of Remating Behaviour inFrontiers in physiology · 2022Article
- Social perception of young adults prolongs the lifespan of aged Drosophila.NPJ aging and mechanisms of disease · 2021Article
- Article
- Sex and Death: Identification of Feedback Neuromodulation Balancing Reproduction and Survival.Neuroscience bulletin · 2020Article
- Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways.GeroScience · 2020Article
- Male reproductive aging arises via multifaceted mating-dependent sperm and seminal proteome declines, but is postponable inProceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Costs of reproduction are thought to result from natural selection optimizing organismal fitness within putative physiological constraints. Phenotypic and population genetic studies of reproductive costs are plentiful across taxa, but an understanding of their mechanistic basis would provide important insight into the diversity in life-history traits, including reproductive effort and ageing. Here, we dissect the causes and consequences of specific costs of reproduction in male Drosophila melanogaster. We find that key survival and physiological costs of reproduction arise from perception of the opposite sex, and they are reversed by the act of mating. In the absence of pheromone perception, males are free from reproductive costs on longevity, stress resistance and fat storage. The costs of perception and the benefits of mating are both mediated by evolutionarily conserved neuropeptidergic signalling molecules, as well as the transcription factor dFoxo. These results provide a molecular framework in which certain costs of reproduction arise as a result of self-imposed 'decisions' in response to perceptive neural circuits, which then orchestrate the control of life-history traits independently of physical or energetic effects associated with mating itself.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.