ArticleNature ecology & evolution2016
Widespread maintenance of genome heterozygosity in Schmidtea mediterranea.
Article in Nature ecology & evolution, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Stepwise emergence of recombination suppression precedes fissiparous asexuality in the planarian Schmidtea mediterranea.Nature communications · 2026Article
- Drift of positional identity drives reproductive aging in a long-lived regenerative animal.Current biology : CB · 2026Article
- The Sensory Basis of Planarian Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Regeneration leads to global tissue rejuvenation in aging sexual planarians.Nature aging · 2025Article
- Highly contiguous genome assembly of Drosophila prolongata-a model for evolution of sexual dimorphism and male-specific innovations.G3 (Bethesda, Md.) · 2024Article
- A comparative analysis of planarian genomes reveals regulatory conservation in the face of rapid structural divergence.Nature communications · 2024Article
- Highly Contiguous Genome Assembly ofbioRxiv : the preprint server for biology · 2024Article
- Genome-wide assessment of genetic diversity and transcript variations in 17 accessions of the model diatomISME communications · 2024Article
- Article
- Ultrafast and long-range coordination of wound responses is essential for whole-body regeneration.bioRxiv : the preprint server for biology · 2023Article
- Heterologous reporter expression in the planarianCell reports methods · 2022Article
- Article
- A Novel Taxon of Monosegmented Double-Stranded RNA Viruses Endemic to Triclad Flatworms.Journal of virology · 2020Article
- Planarians recruit piRNAs for mRNA turnover in adult stem cells.Genes & development · 2019Article
- Insights into regeneration tool box: An animal model approach.Developmental biology · 2019Review
- An adaptable chromosome preparation methodology for use in invertebrate research organisms.BMC biology · 2018Article
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Loss of heterozygosity through inbreeding or mitotic errors leads to reductions in progeny survival and fertility. Loss of heterozygosity is particularly exacerbated in geographically isolated populations, which are prone to inbreeding depression and faster rates of extinction. The regenerative capacities of the hermaphroditic biotype of the planarian Schmidtea mediterranea allowed us to perform a systematic genetic test of Mendelian segregation and study the loss of heterozygosity in the Spiralian superclade in general and planarians in particular. We discovered that ~300 Mb (~37.5%) of the genome retains heterozygosity even after ten generations of inbreeding, and show that these chromosomal regions have low diversity and recombination rates in wild populations. Our genetic and genomic analyses establish S. mediterranea as a genetically tractable system. The research also opens the door to study the evolutionary basis of non-Mendelian mechanisms, the adaptive advantages of chromosome structural heterozygotes and their potential relationship to the robust regenerative capacities of planarians.
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Registered trials
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