Evidence map›Paper›PMID 28812325›Full record

ArticlePsycho-oncology2017

Ambiguity in a masculine world: Being a BRCA1/2 mutation carrier and a man with prostate cancer.

C Moynihan, E K Bancroft, A Mitra, A Ardern-Jones, E Castro, E C Page, R A Eeles

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Psycho-oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00261456 (The IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte Cancer), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00261456 active not recruitingnot on this map

The IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte Cancer: Targeted Screening in Men at Higher Genetic Risk and Controls

TypeobservationalSponsorInstitute of Cancer Research, United KingdomRan2005 to 2030Enrolled3,500ConditionsProstate Cancer, BRCA Mutation, Mismatch Repair Gene Mutation, Genetic Predisposition to DiseaseArmsPSA test, Prostate Biopsy
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Psychological aspects, risk and protective factors related to BRCA genetic testing: a review of the literature.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
  2. Article
  3. An in-depth exploration of the post-test informational needs ofHereditary cancer in clinical practice · 2020
    Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

C MoynihanThe Institute of Cancer Research, London, UK.
E K BancroftThe Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-5482-5660
A MitraThe Institute of Cancer Research, London, UK.
A Ardern-JonesThe Royal Marsden NHS Foundation Trust, London, UK.
E CastroThe Institute of Cancer Research, London, UK.
E C PageThe Institute of Cancer Research, London, UK.
R A EelesThe Institute of Cancer Research, London, UK.ORCID http://orcid.org/0000-0002-3698-6241
Institute of Cancer Research · GBRoyal Marsden NHS Foundation Trust · GBUniversity College Hospital · GB

Funding

Cancer Research UK 17528Cancer Research UK 21332
6 · The paper itself

Abstract

objectiveIncreased risk of prostate cancer (PCa) is observed in men with BRCA1/BRCA2 mutations. Sex and gender are key determinants of health and disease although unequal care exists between the sexes. Stereotypical male attitudes are shown to lead to poor health outcomes.

methodsMen with BRCA1/2 mutations and diagnosed with PCa were identified and invited to participate in a qualitative interview study. Data were analysed using a framework approach. "Masculinity theory" was used to report the impact of having both a BRCA1/2 mutation and PCa.

resultsEleven of 15 eligible men were interviewed. The umbrella concept of "Ambiguity in a Masculine World" was evident. Men's responses often matched those of women in a genetic context. Men's BRCA experience was described, as "on the back burner" but "a bonus" enabling familial detection and early diagnosis of PCa. Embodiment of PCa took precedence as men revealed stereotypical "ideal" masculine responses such as stoicism and control while creating new "masculinities" when faced with the vicissitudes of having 2 gendered conditions.

conclusionHealth workers are urged to take a reflexive approach, void of masculine ideals, a belief in which obfuscates men's experience. Research is required regarding men's support needs in the name of equality of care.

Indexed as

Genes, BRCA1Genes, BRCA2MasculinityMutationAdultGenetic Predisposition to DiseaseHumansInterviews as TopicMaleMenMiddle AgedProstateProstatic NeoplasmsQualitative ResearchSexual BehaviorBRCA1BRCA2gender/masculinityprostate cancerpsychosocial

Identifiers

PMID28812325
PMCPMC5698714
OpenAlexW2749485731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.