Evidence map›Paper›PMID 28812240›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2017

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei and appendix tumours in elderly patients: Is it justified?

V López-López, P A Cascales-Campos, E Gil, J Arevalo, A Gonzalez, J Gil, F C Muñoz-Casares, J T Melero, P Barrios, R Morales and 8 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

V López-LópezSurgery Department, Clinic Universitary Hospital of Virgen De La Arrixaca, IMIB, Arrixaca, Carretera Madrid-Cartagena S/N. El Palmar, 30120, Murcia, Spain.ORCID http://orcid.org/0000-0003-1718-3352
P A Cascales-CamposSurgery Department, Clinic Universitary Hospital of Virgen De La Arrixaca, IMIB, Arrixaca, Carretera Madrid-Cartagena S/N. El Palmar, 30120, Murcia, Spain. cascalescirugia@gmail.com.
E GilSurgery Department, Clinic Universitary Hospital of Virgen De La Arrixaca, IMIB, Arrixaca, Carretera Madrid-Cartagena S/N. El Palmar, 30120, Murcia, Spain.
J ArevaloRadiology Departament, Memorial Sloan Kettering Cancer Center, New York, USA.
A GonzalezSurgery Department, Clinic Universitary Hospital of Virgen De La Arrixaca, IMIB, Arrixaca, Carretera Madrid-Cartagena S/N. El Palmar, 30120, Murcia, Spain.
J GilSurgery Department, Clinic Universitary Hospital of Virgen De La Arrixaca, IMIB, Arrixaca, Carretera Madrid-Cartagena S/N. El Palmar, 30120, Murcia, Spain.
F C Muñoz-CasaresHospital Universitario Virgen del Rocio, Sevilla, Andalucia, Spain.
J T MeleroHospital Universitario De Torrecárdenas, Almería, Andalucia, Spain.
P BarriosHospital De Sant Joan De Espi Moises Broggi, Sant Joan De Espi, Cataluña, Spain.
R MoralesHospital Universitario Son Espases, Palma de Mayorca, Islas Baleares, Spain.
I RamosHospital De Sant Joan De Espi Moises Broggi, Sant Joan De Espi, Cataluña, Spain.
G OrtegaHospital Universitario De Fuenlabrada, Madrid, Spain.
B CampsHospital General Universitario Valencia, Valencia, Spain.
L González-BayónHospital General Universitario Gregorio Marañón, Madrid, Spain.
P Bretcha-BoixHospital Quirón de Torrevieja, Alicante, Comunidad Valenciana, Spain.
J Farré-AlegreHospital Quirón de Torrevieja, Alicante, Comunidad Valenciana, Spain.
S González-MorenoMD Anderson Cancer Center, Madrid, Spain.
P ParrillaSurgery Department, Clinic Universitary Hospital of Virgen De La Arrixaca, IMIB, Arrixaca, Carretera Madrid-Cartagena S/N. El Palmar, 30120, Murcia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for pseudomyxoma peritonei and appendix tumours are widespread in the world. It is unclear what should be the attitude in elderly patients.

methodsThis retrospective multicenter study collected the database from ten Spanish centers from Spanish Group of Peritoneal Cancer Surgery. The study period was between November 2002 and March 2014. Seventeen patients with age greater than or equal to 75 years with peritoneal carcinomatosis from pseudomyxoma peritonei and appendix tumours met the selection criteria for the study. Outcomes in terms of morbidity and mortality such as disease-free and overall survival were analyzed.

resultsMedian PCI was 16 (range 6-39). Ten postoperative adverse events were detected in nine patients (44.4%). 28% were grade I-II and 17% were grade III-IV. Disease-free survival at 1 and 3 years was 67 and 44%, respectively. Overall survival at 1 and 3 years was 100 and 88%, respectively. Only cytoreduction was related to worst disease free survival after univariate (p = 0.007) and multivariate (OR 11.639, 95% CI 1.24-109.74, p = 0.03) analyses. Cytoreduction was related to the worst overall survival after univariate analysis (p = 0.046).

conclusionCytoreductive surgery and HIPEC for pseudomyxoma peritonei and appendix tumours in elderly patients it is a procedure with feasible postoperative morbi-mortality and survival outcomes.

trial registrationresearchregistry1587 (retrospectively registered).

Indexed as

AgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsAppendiceal NeoplasmsChemotherapy, Cancer, Regional PerfusionCombined Modality TherapyCytoreduction Surgical ProceduresFemaleFollow-Up StudiesHumansHyperthermia, InducedMalePeritoneal NeoplasmsPrognosisPseudomyxoma PeritoneiRetrospective StudiesAppendixElderlyHIPECMorbidityPseudomyxoma peritoneiSurvival

Identifiers

PMID28812240

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.